{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:14:00Z","timestamp":1789992840693,"version":"4.0.1"},"reference-count":55,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171429"],"award-info":[{"award-number":["82171429"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Dietary interventions alleviate Parkinson's disease (PD) progression by modulating the gut microbiota. However, the interaction between time\u2010restricted feeding (TRF) and dietary protein composition remains unclear. This study examines the effects of casein (animal\u2010derived) and soy protein (plant\u2010derived) on PD pathology in an MPTP\u2010induced mouse model and their influence on TRF efficacy. MPTP induces dopaminergic neuron loss and neuroinflammation regardless of protein source, but casein\u2010fed mice show partial motor dysfunction and gut barrier disruption, whereas soy protein\u2010fed mice maintain motor function and barrier integrity. TRF differentially modulates PD outcomes: in casein\u2010fed mice, it alleviates partial motor deficits by suppressing monoamine oxidase B (MAO\u2010B) and reducing dopamine (DA) metabolism, without rescuing DA levels or neuron survival. In soy protein\u2010fed mice, TRF suppresses MAO\u2010B, preserves dopaminergic neurons, restores DA levels, and reduces neuroinflammation. Analysis of gut microbiota and metabolomics suggests that TRF may reduce\n                    <jats:italic>Allobaculum<\/jats:italic>\n                    and branched\u2010chain amino acids (BCAAs) in casein\u2010fed mice, while increasing\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    and short\u2010chain fatty acids (SCFAs) in soy protein\u2010fed mice. Mechanistic assays suggest that\n                    <jats:italic>Allobaculum<\/jats:italic>\n                    and BCAAs impair gut barrier function and aggravate inflammation. In conclusion, TRF exerts protein\u2010dependent neuroprotective effects, with soy protein combined with TRF offering a promising dietary strategy for PD management.\n                  <\/jats:p>","DOI":"10.1002\/advs.202516502","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T07:08:58Z","timestamp":1769497738000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neuroprotective Effects of Time\u2010Restricted Feeding Combined With Different Protein Sources in MPTP\u2010Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota Metabolism"],"prefix":"10.1002","volume":"13","author":[{"given":"Ting","family":"Li","sequence":"first","affiliation":[{"name":"Laboratory of Neurodegenerative Disease School of Medicine Jiangnan University  Wuxi Jiangsu China"},{"name":"MOE Medical Basic Research Innovation Center for Gut Microbiota and Chronic Diseases School of Medicine Jiangnan University  Wuxi Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wu","sequence":"additional","affiliation":[{"name":"Laboratory of Neurodegenerative Disease School of Medicine Jiangnan University  Wuxi Jiangsu China"},{"name":"MOE Medical Basic Research Innovation Center for Gut Microbiota and Chronic Diseases School of Medicine Jiangnan University  Wuxi Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Yang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Laboratory of Neurodegenerative Disease School of Medicine Jiangnan University  Wuxi Jiangsu China"},{"name":"MOE Medical Basic Research Innovation Center for Gut Microbiota and Chronic Diseases School of Medicine Jiangnan University  Wuxi Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010An","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of 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