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Cytokines and chemokines significantly affect the pathogenesis of SCI and represent important targets for therapeutic intervention. Here, dozens of cytokines and chemokines are dynamically monitored in plasma, cerebrospinal fluid, and injury site released in response to experimental SCI conducted in two rodent strains and patients undergoing surgical removal of intramedullary tumors. Dataset comprising 6,172 cytokine\/chemokine values across 8 time points suggests that SCI in mammals is accompanied by a massive cytokine storm in cerebrospinal fluid, mainly driven by CXCL1, IL\u20106, and CCL2\u20105. Sub\u2010acute phase is mostly associated with IL\u20102, IL\u20107, CCL22 and CX3CL1, whereas TNF\u03b1 and IL17\u03b1 permanently persists in CNS for even weeks following SCI. The effects of mogamulizumab and chemical antagonists of C\u2010C\/C\u2010X\u2010C chemokine receptors TAK\u2010799, SB225002, and MK\u20107123 on SCI recovery in rodents are further estimated. Here blockade of CCR5 and CXCR1\/2 chemokine receptors is shown beneficial for amelioration of acute SCI, whereas anti\u2010CCR4 antibody mogamulizumab readily prevents secondary inflammation in the injured area. Summarizing, the current report claims for a novel combined time\u2010resolved therapeutic modality in SCI treatment, which supports feasibility and motivates off\u2010label clinical evaluation in appropriate cohorts.<\/jats:p>","DOI":"10.1002\/advs.202516569","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:46:15Z","timestamp":1761662775000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Repurposing of Chemokine Antagonists for Combined Phase\u2010Resolved Spinal Cord Injury Treatment"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2033-9621","authenticated-orcid":false,"suffix":"Jr.","given":"Alexey A.","family":"Belogurov","sequence":"first","affiliation":[{"name":"Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences  Moscow 117997 Russia"},{"name":"Department of Biological Chemistry Russian University of Medicine Ministry of Health of Russian Federation  Moscow 127473 Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgii B.","family":"Telegin","sequence":"additional","affiliation":[{"name":"Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences  Pushchino 142290 Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandr S.","family":"Chernov","sequence":"additional","affiliation":[{"name":"Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences  Moscow 117997 Russia"},{"name":"Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences  Pushchino 142290 Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna A.","family":"Kudriaeva","sequence":"additional","affiliation":[{"name":"Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences  Moscow 117997 Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey N.","family":"Minakov","sequence":"additional","affiliation":[{"name":"Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences  Moscow 117997 Russia"},{"name":"Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences  Pushchino 142290 Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maksim V.","family":"Rodionov","sequence":"additional","affiliation":[{"name":"Medical Radiological Research Center (MRRC) named after A.F. 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