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In this study, we develop a nitrogen\u2010doped iron\/cobalt dual\u2010atom catalyst (FeCo\u2010N\u2010DAC) with high metal loading (Fe &gt; 5.4%, Co &gt; 4.8%) as a multifunctional platform that integrates nanozyme\u2010mimicking catalytic activity and photothermal therapy. FeCo\u2010N\u2010DAC mimics multiple natural enzymes to generate reactive oxygen species, disrupt bacterial biofilms, and eradicate methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA) in both murine and porcine models of subcutaneous abscesses and infectious wounds, respectively. Upon near\u2010infrared (NIR\u2010II) irradiation, the material exhibits deep\u2010seated tissue penetration and synergistic catalytic\u2010photothermal effects, enabling complete biofilm clearance in otherwise recalcitrant infections. Multi\u2010omics analyses, including transcriptomics and proteomics, reveal that FeCo\u2010N\u2010DAC modulates immune responses and promotes tissue regeneration by reprogramming inflammation\u2010 and fibrosis\u2010related pathways. This study highlights the therapeutic potential of dual\u2010atom nanozymes for precision anti\u2010infective therapy and underscores their translational relevance in treating complex, biofilm\u2010associated infections.\n                  <\/jats:p>","DOI":"10.1002\/advs.202516783","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T09:51:49Z","timestamp":1766829109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Iron\/Cobalt Dual\u2010Atom Catalyst Orchestrate Photothermal\u2010Chemodynamic Immunotherapy Against MRSA: Multi\u2010Omics Dissection in Murine and Porcine Models"],"prefix":"10.1002","volume":"13","author":[{"given":"Shihao","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Ultrasound Medicine National Key Clinical Specialty (Wound Healing) Wenzhou Key Laboratory of Interventional Ultrasound for Intelligent Healthcare and Clinical 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