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Here, we optimized a magnetic resonance imaging protocol to quantitatively analyze mLV structure and drainage function. Using murine lung adenocarcinoma brain metastasis models and clinical imaging data, we reveal significant mLV disruption surrounding the superior sagittal sinus (SSS), which results in impaired drainage to deep cervical lymph nodes (dCLNs). Among ten cervical lymph\u2010node levels assessed clinically, level IIA lymph nodes most accurately reflect mLV drainage efficiency. Functionally, mLV ablation compromised intrathecal chemotherapy efficacy in mice, while clinically, greater mLV structural and functional impairment correlates with disease progression in lung adenocarcinoma brain metastasis. Collectively, our findings demonstrate that lung adenocarcinoma brain metastases disrupt SSS\u2010adjacent mLVs (mLVs\u2010SSS), which potentially facilitates metastatic progression through compromised immune surveillance.<\/jats:p>","DOI":"10.1002\/advs.202516988","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T19:09:11Z","timestamp":1768504151000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0543-5022","authenticated-orcid":false,"given":"Yuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"Beijing Neurosurgical Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shucheng","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"Beijing Neurosurgical Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penghui","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"Beijing Neurosurgical Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Yin","sequence":"additional","affiliation":[{"name":"Clinical Trial Research Center Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichun","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Oncology Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosheng","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Oncology Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"Tiantan Neuroimaging Center of Excellence Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai United Imaging Healthcare Co., Ltd  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Han","sequence":"additional","affiliation":[{"name":"Wuhan United Imaging Life Science Instrument Co., Ltd  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baowang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"Beijing Neurosurgical Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"Beijing Neurosurgical Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Trial Research Center Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"Beijing Neurosurgical Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"Tiantan Neuroimaging Center of Excellence Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center For Neurological Diseases Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shi","sequence":"additional","affiliation":[{"name":"Beijing Institute for Brain Research Chinese Academy of Medical Sciences &amp; 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