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Herein, we engineered self\u2010assembling nanoparticles composed entirely of POEGMA by designing AB diblock copolymers with varying oligo(ethylene glycol) (EG) side chains. We found that a one\u2010unit difference between di\u2010 and tri\u2010ethylene glycol side chains is sufficient to induce amphiphilicity and enables temperature\u2010triggered self\u2010assembly above room temperature when the block length ratio is at least 0.25. To broaden the temperature stability window, we increased amphiphilicity by incorporating mono\u2010ethylene glycol into the hydrophobic block via random copolymerization, yielding nanoparticles stable between 20\u00b0C\u201340\u00b0C. These POEGMA nanoparticles effectively encapsulate diverse hydrophobic drugs with high loading efficiency. Notably, POEGMA\u2010encapsulated doxorubicin retained the drug's in vitro activity and exhibited enhanced in vivo efficacy compared to free doxorubicin due to improved pharmacokinetics. Furthermore, these nanoparticles demonstrated stealth behavior by evading recognition by anti\u2010PEG antibodies. This study introduces a versatile, fully POEGMA\u2010based platform for stealth drug delivery with tunable thermal responsiveness and high therapeutic potential.<\/jats:p>","DOI":"10.1002\/advs.202517048","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T03:57:28Z","timestamp":1768795048000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["All\u2010PEG\u2010Like Block Copolymers Self\u2010Assemble into Stealth Nanocarriers for Drug Delivery"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5791-3383","authenticated-orcid":false,"given":"Parul","family":"Sirohi","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke E.","family":"Silverstein","sequence":"additional","affiliation":[{"name":"Department of 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