{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:22:59Z","timestamp":1783113779164,"version":"3.54.6"},"reference-count":68,"publisher":"Wiley","issue":"34","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473713"],"award-info":[{"award-number":["82473713"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173602"],"award-info":[{"award-number":["82173602"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified\n                    <jats:italic>Gemella morbillorum<\/jats:italic>\n                    as a key contributor to the CRC\u2010associated microbiota. Fluorescence in situ hybridization revealed that\n                    <jats:italic>Gemella morbillorum<\/jats:italic>\n                    is enriched in CRC tumor tissues compared to adjacent normal tissues. In vitro and in vivo experiments elucidated the oncogenic effects of\n                    <jats:italic>Gemella morbillorum<\/jats:italic>\n                    on human CRC cell lines and mouse models. Multimodal imaging shows that\n                    <jats:italic>Gemella morbillorum<\/jats:italic>\n                    can internalize into host cells. RNA sequencing, co\u2010immunoprecipitation, and mass spectrometry identified that\n                    <jats:italic>Gemella morbillorum<\/jats:italic>\n                    invades host cells via interaction between its LysM peptidoglycan\u2010binding domain protein (LPBDCP) and host cell surface transmembrane protein TMEM140. This invasion triggers Ca\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    influx, downregulates RASA4, and activates the PI3K\u2010AKT\u2010NF\u2010\u03baB and RAF\u2010MEK\u2010ERK signaling pathways. Following invasion,\n                    <jats:italic>Gemella morbillorum<\/jats:italic>\n                    secretes NAD\u2010dependent protein deacetylase (NDPD), which induces p53 deacetylation and degradation. Collectively, these events accelerate cell proliferation, shorten the cell cycle, and inhibit apoptosis, thereby promoting malignant transformation. Genetic knockout of LPBDCP or TMEM140 effectively inhibits bacterial invasion and abrogates the oncogenic effects of\n                    <jats:italic>Gemella morbillorum<\/jats:italic>\n                    . In tumor\u2010bearing mice, knockout of LPBDCP or NDPD eliminates the tumor\u2010promoting effects of\n                    <jats:italic>Gemella morbillorum<\/jats:italic>\n                    . These results underscore\n                    <jats:italic>Gemella morbillorum<\/jats:italic>\n                    \u2019s role in CRC and pinpoint potential intervention targets.\n                  <\/jats:p>","DOI":"10.1002\/advs.202517245","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T10:50:58Z","timestamp":1775559058000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Gemella morbillorum<\/i>\n                    Promotes Colorectal Carcinogenesis: LPBDCP\u2010Mediated Invasion Activates Ras Signaling and Destabilizes p53"],"prefix":"10.1002","volume":"13","author":[{"given":"Zhen","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Ministry of Education Key Lab of Environment and Health Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Ministry of Education Key Lab of Environment and Health Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei P. R. China"},{"name":"Public Health Service Center, Bao'an District, Shenzhen Shenzhen Guangdong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojie","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Ministry of Education Key Lab of Environment and Health Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Ministry of Education Key Lab of Environment and Health Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaishuai","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Ministry of Education Key Lab of Environment and Health Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Ministry of Education Key Lab of Environment and Health Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Ministry of Education Key Lab of Environment and Health Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institutional Center For Shared Technologies and Facilities of Wuhan Institute of Virology Chinese Academy of Sciences  Wuhan Hubei P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7455-1735","authenticated-orcid":false,"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Ministry of Education Key Lab of Environment and Health Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei P. R. China"},{"name":"Hubei Cancer Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei P. R. China"},{"name":"Hubei Provincial Clinical Research Center for Colorectal Cancer  Wuhan Hubei P. R. China"},{"name":"Wuhan Clinical Research Center For Colorectal Cancer  Wuhan Hubei P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.01.017"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.10.012"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)32319\u20100"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102021\u2010325851"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010024\u201002963\u20102"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12469"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010022\u201000513\u2010x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010med\u2010080719\u2010091604"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201025965\u2010x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001123"},{"key":"e_1_2_12_12_1","unstructured":"Gemella morbillorum. Updated: November 9 2023. [Internet] https:\/\/www.drugs.com\/pathogens\/gemella\u2010morbillorum.html."},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.04.028"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217077"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.05.002"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09973"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1716055115"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010015\u20100187\u20104"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201023683\u2010y"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201642833"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1471\u20104906(00)01795\u20106"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0960\u20109822(01)00261\u20105"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010021\u201001284\u20106"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010biochem\u2010052521\u2010040754"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111596"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.04.009"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1810918"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1097\u20102765(04)00082\u20106"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.312498"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476\u20104598\u20108\u201085"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1303628110"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.18.2831"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.11.026"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249533"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601567"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201046888\u20103"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010025\u201003693\u20109"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.ads6166"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005435\u20100"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkae022"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.825076"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1776475"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00219"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15827"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2022.07.004"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002430\u20107"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2002162118"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2022.05.005"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202309370"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102541\u20100"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.12.032"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.2128"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418\u2010022\u201000999\u2010w"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature737"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201009\u20102661"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2003193118"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1724"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541\u20107786.MCR\u201006\u20100201"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326\u20106066.CIR\u201014\u20100095"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002888\u20105"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7528"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.04.018"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102018\u2010317178"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564\u2010021\u201001030\u20107"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty648"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.06.038"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty734"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002687"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202517245","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202517245","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202517245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:54:51Z","timestamp":1783112091000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202517245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,7]]},"references-count":68,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/advs.202517245"],"URL":"https:\/\/doi.org\/10.1002\/advs.202517245","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,7]]},"assertion":[{"value":"2025-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e17245"}}