{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T23:12:35Z","timestamp":1787094755806,"version":"build-2736575974"},"reference-count":65,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970090"],"award-info":[{"award-number":["31970090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Wound healing represents a complex biological process necessitating innovative therapeutic approaches, particularly for chronic wounds such as diabetic foot ulcers (DFUs). Inspired by the regenerative effects of tibial bone transport for DFUs, we explored whether radial extracorporeal shockwave therapy (rESWT) at the tibial annular osteotomy site (TOE) could enhance wound healing in rats. We found that TOE accelerated dorsal foot wound healing via small extracellular vesicles (sEV). This sEVs showed strong regenerative effects and modulated macrophage polarizations in vitro and in vivo. Single\u2010cell sequencing revealed mesenchymal stem cells as the likely sEV source, with rESWT triggering sEV release through ATP\/P2X7R\/p38MAPK pathway. Proteomic analysis identified five differentially expressed proteins in sEVs, with Thrombospondin 1 (Thbs1)\u2010enhanced sEVs enhancing wound healing by promoting IL4\u2010induced M2 macrophage polarization. This innovative approach represents a promising alternative strategy for wound management, with potential for future DFU treatment.<\/jats:p>","DOI":"10.1002\/advs.202517257","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T13:29:01Z","timestamp":1767878941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early Radial Extracorporeal Shockwave Stimulation on Proximal Tibial Circular Osteotomy Site Enhanced Heterotopic Skin Wound Healing via Small Extracellular Vesicles"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9402-4112","authenticated-orcid":false,"given":"Xiaoping","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Orthopedics Orthopedics Center The First Hospital of Jilin University Jilin University Changchun  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2168-9623","authenticated-orcid":false,"given":"Songqi","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Orthopedics Center The First Hospital of Jilin University Jilin University Changchun  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9254-6461","authenticated-orcid":false,"given":"Bang","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Hand and Podiatric Surgery Orthopedics Center The First Hospital of Jilin University Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongqi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Orthopedics Center The First Hospital of Jilin University Jilin University Changchun  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Orthopedics Center The First Hospital of Jilin University Jilin University Changchun  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8825-0094","authenticated-orcid":false,"given":"Zhixing","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Orthopedics Center The First Hospital of Jilin University Jilin University Changchun  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Orthopedics Center The First Hospital of Jilin University Jilin University Changchun  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanxu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Orthopedics Center The First Hospital of Jilin University Jilin University Changchun  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3456-5942","authenticated-orcid":false,"given":"Tiecheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Orthopedics Center The First Hospital of Jilin University Jilin University Changchun  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00419"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2020.04.004"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2017.07.007"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13047\u2010020\u201000383\u20102"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010020\u201001415\u20108"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S276001"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198902000-00029"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010018\u20100650\u20109"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1095361"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101588"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/CORR.0000000000001075"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2022.09.002"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/os.13214"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12566"},{"issue":"6","key":"e_1_2_11_16_1","article-title":"Extracorporeal Shock Wave Therapy for the Healing and Management of Venous Leg Ulcers","volume":"6","author":"Cooper B.","year":"2018","journal-title":"Cochrane Database of Systematic Reviews (Online)"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u2010475X.2008.00444.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2007.01.009"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2008.01.026"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14035"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/kjm2.12746"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9010021"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12686"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182121d6e"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2015.07.719"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22157844"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140541"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2021.116186"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2024.117196"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201700797"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2023.09.001"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1356"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adp2974"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/10711007251341312"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2021.04.006"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13916"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.037912"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14518"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010020\u201002076\u2010w"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010018\u20100805\u20105"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100030\u20101255354"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109610(03)00296\u20104"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009337"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.8879"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2014.05.004"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1596"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.08.029"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9051157"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12993"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.01.030"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2023.110573"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2023.112089"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24129805"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.12.027"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201050045\u20101"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/296069"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.13.3272"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.302104"},{"key":"e_1_2_11_59_1","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.2147\/DMSO.S424847","article-title":"MicroRNA\u2010221\u20103p Targets THBS1 to Promote Wound Healing in Diabetes","volume":"16","author":"Hu K.","year":"2023","journal-title":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104130"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2014.05.003"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109440(10)64243\u20105"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2023.05.008"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007237\u2010y"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.06.023"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2022.08.004"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202517257","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202517257","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202517257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T08:51:08Z","timestamp":1773823868000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202517257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":65,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/advs.202517257"],"URL":"https:\/\/doi.org\/10.1002\/advs.202517257","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,8]]},"assertion":[{"value":"2025-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e17257"}}