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Here eIF5A highly expressed in diverse spermatogenic cell types are found. Conditional knockout of\n                    <jats:italic>Eif5a<\/jats:italic>\n                    (SKO) causes complete infertility in male mice due to round spermatid arrest. Interestingly, eIF5A deletion severely compromises chromocenter integrity in round spermatids. Proteomic profiling reveals widespread dysregulation in eIF5A\u2010deficient round spermatids, downregulated proteins are enriched for chromatin\u2010associated functions, likely contributing to chromocenter dysfunction. Notably, ATAC\u2010seq (Assay for Transposase\u2010Accessible Chromatin with high\u2010throughput sequencing)\u00a0analysis shows increased chromatin accessibility upon eIF5A depletion, accompanied by transcriptional dysregulation of genes critical for acrosome and manchette formation. This data underscore that eIF5A not only regulates the translation of chromatin\u2010organizing proteins required for chromocenter stability but also influences transcriptional regulation by modulating chromatin landscape. These findings illuminate a previously uncharacterized and germ cell\u2010specific pathway coupling translational control and transcriptional regulation via chromatin reorganization.\n                  <\/jats:p>","DOI":"10.1002\/advs.202517423","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T07:31:39Z","timestamp":1767598299000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["EIF5A Couples Translational Control With Transcriptional Reprogramming Through Chromocenter Reorganization During Spermiogenesis"],"prefix":"10.1002","volume":"13","author":[{"given":"Yuling","family":"Cai","sequence":"first","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health Center for Reproductive Medicine Institute of Women Children and Reproductive Health Shandong University  Jinan 250012 China"},{"name":"National Research Center for Assisted Reproductive 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