{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:30:32Z","timestamp":1791001832285,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    MRSA infections give rise to chronic cutaneous and advance into profound tissue invasions, including osteomyelitis and sepsis\u2014conditions for which existing clinical interventions offer only limited efficacy. The utility of broad\u2010spectrum antibiotics has become increasingly compromised by escalating drug resistance, inadequate tissue targeting, and deleterious side effects. Neutrophil extracellular traps (NETs) have emerged as a compelling immunotherapeutic avenue for eradicating multidrug\u2010resistant pathogens. Inspired by the bactericidal and immunoregulatory functions of NETs, we developed a photothermal\u2013immunomodulatory hydrogel reinforced by a Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    \/ZnAl\u2010LDH nanoplatform to mimic NETs\u2010like antimicrobial defense while overcoming their inherent limitations. Hollow photothermal nanoparticles were fabricated from 2D Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    and ZnAl\u2010LDH (TiZ) nanosheets and infused with chlorogenic acid, forming CTiZ. These were cloaked in membranes derived from apoptotic neutrophils to create a NETs\u2010mimetic functional bacterial trapper (CTiZM), which was then encapsulated within a thermoresponsive dopa\u2010poly(N\u2010isopropylacrylamide) hydrogel (dopa\u2010PNIPAm, DP), yielding a composite hydrogel system designated CTiZM@DP. This sophisticated platform amplifies antibacterial potency through effective microbial entrapment and the generation of reactive oxygen species, while simultaneously orchestrating the polarization of macrophages toward a reparative M2 phenotype under the influence of gentle photothermal stimulation. Collectively, this integrative strategy heralds a promising therapeutic modality for the eradication of multidrug\u2010resistant infections and the enhancement of wound healing in individuals with diabetes.\n                  <\/jats:p>","DOI":"10.1002\/advs.202517577","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T12:00:47Z","timestamp":1768910447000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Photothermal\u2013Immunomodulatory Hydrogel Reinforced by Ti\n                    <sub>3<\/sub>\n                    C\n                    <sub>2<\/sub>\n                    \/ZnAl\u2010LDH Nanoplatform for Eradicating MRSA and Promoting Diabetic Wound Healing"],"prefix":"10.1002","volume":"13","author":[{"given":"Qiang","family":"Shi","sequence":"first","affiliation":[{"name":"Department of orthopaedics The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renliang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Orthopedics Research Institute Department of Orthopedics West China Hospital Sichuan University  Chengdu P. R. China"},{"name":"Trauma Medical Center Department of Orthopedics Surgery West China Hospital Sichuan University  Chengdu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of orthopaedics The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenchen","family":"Xiong","sequence":"additional","affiliation":[{"name":"Orthopedics Research Institute Department of Orthopedics West China Hospital Sichuan University  Chengdu P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9782-4503","authenticated-orcid":false,"given":"Wenzhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of orthopaedics The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui P. R. 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