{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:00:18Z","timestamp":1790373618048,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470615"],"award-info":[{"award-number":["82470615"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022MH217"],"award-info":[{"award-number":["ZR2022MH217"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFA1310200"],"award-info":[{"award-number":["2025YFA1310200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Metabolic dysfunction\u2010associated steatotic liver disease (MASLD) is a common chronic liver disease. This study investigates the anti\u2010MASLD effects of dietary prebiotic stachyose (STA) on disease progression identifying\n                    <jats:italic>Butyricimonas virosa<\/jats:italic>\n                    as a key bacterium boosted by STA supplementation. Oral gavage of\n                    <jats:italic>B. virosa<\/jats:italic>\n                    to high fat diet (HFD)\u2010fed mice significantly suppresses the progression of MASLD and modulates gut microbiota composition. Integration of metagenomic and metabolomic data demonstrates that\n                    <jats:italic>B. virosa<\/jats:italic>\n                    treatment significantly enhances the production of thiamine monophosphate (TMP), as well as its conversion to thiamine and subsequent accumulation in the liver. The accumulation of hepatic thiamine further leads to elevated thiamine pyrophosphate (TPP) concentrations enhancing the activity of branched\u2010chain \u03b1\u2010keto acid dehydrogenase E1 subunit \u03b1 (BCKDHA) associated with augmented degradation of branched chain amino acids (BCAAs). Administration of\n                    <jats:italic>B. virosa<\/jats:italic>\n                    compensates via production of gut bacterial\u2010derived TMP for hepatic TPP deficiency in mice fed a thiamine\u2010deficient HFD. A population\u2010based analysis reveals an inverse correlation between plasma thiamine levels, abundances of bacterial genes involved in thiamine synthesis and metabolism, and phenotypes associated with MASLD, suggesting that key genes involved in fecal thiamine metabolism, as well as serum thiamine determination, may potentially serve as biomarkers for the diagnosis of MASLD.\n                  <\/jats:p>","DOI":"10.1002\/advs.202517596","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:32:01Z","timestamp":1768977121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Gut Commensal\n                    <i>Butyricimonas Virosa<\/i>\n                    Modulates Gut Microbiota\u2010Dependent Thiamine Metabolism and Attenuates Mouse Steatotic Liver Disease"],"prefix":"10.1002","volume":"13","author":[{"given":"Ningning","family":"He","sequence":"first","affiliation":[{"name":"School of Basic Medicine, Qingdao Medical College Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8236-3187","authenticated-orcid":false,"given":"Haoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genome and Multi\u2010omics Technologies BGI Research  Shenzhen China"},{"name":"College of Life Sciences University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zizhen","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Qingdao Medical College Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Qingdao Medical College Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Qingdao Medical College Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiwei","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Qingdao Medical College Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhinan","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genome and Multi\u2010omics Technologies BGI Research  Shenzhen China"},{"name":"College of Life Sciences University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinnan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Human commensal microorganisms and Health Research, BGI Research  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hewei","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genome and Multi\u2010omics Technologies BGI Research  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genome and Multi\u2010omics Technologies BGI Research  Shenzhen China"},{"name":"College of Life Sciences University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genome and Multi\u2010omics Technologies BGI Research  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyi","family":"Zhong","sequence":"additional","affiliation":[{"name":"BGI Precision Nutrition  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"BGI Precision Nutrition  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genome and Multi\u2010omics Technologies BGI Research  Shenzhen China"},{"name":"BGI Precision Nutrition  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Kristiansen","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Biomedicine, Department of Biology University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixing","family":"Peng","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Human commensal microorganisms and Health Research, BGI Research  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqiang","family":"Zou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genome and Multi\u2010omics Technologies BGI Research  Shenzhen China"},{"name":"BGI Precision Nutrition  Shenzhen China"},{"name":"Shenzhen Key Laboratory of Human commensal microorganisms and Health Research  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1464-3763","authenticated-orcid":false,"given":"Shangyong","family":"Li","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Qingdao Medical College Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)01811\u20107"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100104\u20109"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.12.012"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(24)00318\u20108"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010020\u20100269\u20109"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2020.109288"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2024.01.009"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101886"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2024.106106"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2016.02.005"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01226"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010019\u20100495\u20102"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.007674\u20100"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.858192"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12113380"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/20420188241242937"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.870785"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1031502"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/pmj\u20102022\u2010141972"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2018.01.009"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2015.00148"},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41684-021-00804-0","article-title":"Delivery of Microbial Metabolites via the Portal Vein","volume":"50","author":"Le Bras A.","year":"2021","journal-title":"Lab Animal"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi401618y"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.048355"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/29933935.2025.2459599"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201037396\u2010x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010018\u20100008\u20108"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fm.2022.104055"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2006.03.027"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197\u2010019\u201003675\u2010z"},{"key":"e_1_2_10_32_1","first-page":"1313","article-title":"Peroxiredoxin 6, a Novel Player in the Pathogenesis of Diabetes. Diabetes","volume":"63","author":"Pacifici F.","year":"2005","journal-title":"Hepatology"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010019\u20101891\u20100"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj\u2010cs.104"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201004648\u20107"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msab293"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb\u20102011\u201012\u20106\u2010r60"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010021\u201000968\u2010y"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421\u2010020\u201000239\u2010w"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.enzmictec.2023.110276"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad326"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201034537\u20106"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2016.05.058"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2139979"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3FO02168H"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c01387"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2023.08.003"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.78.072407.102340"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866\u2010019\u20101433\u20107"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002030050713"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18646"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.80749"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201043261\u20108"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01316"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmr.2024.100018"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201058500\u20103"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2024.0811"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.136416"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.07.011"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.09.017"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035\u2010022\u201000323\u2010z"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102022\u2010329849"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00116-17"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2025.04.020"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.114.007526"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.08.030"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202517596","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202517596","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202517596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:21:34Z","timestamp":1790371294000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202517596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,20]]},"references-count":66,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/advs.202517596"],"URL":"https:\/\/doi.org\/10.1002\/advs.202517596","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,20]]},"assertion":[{"value":"2025-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e17596"}}