{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:22:07Z","timestamp":1783113727879,"version":"3.54.6"},"reference-count":169,"publisher":"Wiley","issue":"34","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005617","name":"BHF Centre of Research Excellence, Oxford","doi-asserted-by":"publisher","award":["RE\/18\/3\/34214"],"award-info":[{"award-number":["RE\/18\/3\/34214"]}],"id":[{"id":"10.13039\/501100005617","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/19\/32\/34376"],"award-info":[{"award-number":["FS\/19\/32\/34376"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/19\/31\/34158"],"award-info":[{"award-number":["FS\/19\/31\/34158"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The embryonic coelomic mesothelium acts as a critical progenitor hub during mammalian organogenesis, undergoing epithelial\u2010to\u2010mesenchymal transition (EMT) to drive vascular growth and parenchymal development in visceral organs. A prominent example is the epicardium, which plays an essential role during heart development. The principles of gene regulation in the coelomic mesothelium remain poorly defined. Specifically, it is unclear how cis\u2010regulatory elements, including enhancers, orchestrate the spatiotemporal patterns of gene expression required for mesothelial identity and function. Here, a multi\u2010omic approach was used to identify trans\u2010 and cis\u2010regulatory elements that regulate mesothelial gene expression in three organs: heart, lung, and pancreas. This analysis uncovers a cardiac\u2010specific regulatory circuit in which the transcription factor (TF) TBX20 selectively activates epicardial enhancers to orchestrate essential developmental programs. In contrast, TF MAF orchestrates pan\u2010mesothelial gene expression via conserved CREs, which are absent in non\u2010mesothelial lineages. Our integrated genomic analysis reveals MAF as a central custodian of mesothelial identity, a role underscored by its negative correlation with EMT, evolutionary conservation, and dynamic regulatory activity throughout development. Our work establishes a foundational blueprint of the gene regulatory landscape governing the coelomic mesothelium, defining both conserved principles and organ\u2010specific mechanisms of spatiotemporal gene expression during early mammalian development.<\/jats:p>","DOI":"10.1002\/advs.202517640","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:53:08Z","timestamp":1775281988000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Organ\u2010Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7083-8560","authenticated-orcid":false,"given":"Quang Minh","family":"Dang","sequence":"first","affiliation":[{"name":"Institute of Developmental and Regenerative Medicine Department of Physiology, Anatomy &amp; Genetics University of Oxford  Oxford UK"},{"name":"Division of Medical Genetics &amp; Rare Diseases Vinmec International Healthcare System  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3501-7254","authenticated-orcid":false,"given":"Nicola","family":"Smart","sequence":"additional","affiliation":[{"name":"Institute of Developmental and Regenerative Medicine Department of Physiology, Anatomy &amp; Genetics University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3620-4983","authenticated-orcid":false,"given":"Andia Nicole","family":"Redpath","sequence":"additional","affiliation":[{"name":"Institute of Developmental and Regenerative Medicine Department of Physiology, Anatomy &amp; Genetics University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2023-6304","authenticated-orcid":false,"given":"Joaquim Miguel","family":"Vieira","sequence":"additional","affiliation":[{"name":"School of Cardiovascular &amp; Metabolic Medicine &amp; Sciences British Heart Foundation Centre of Research Excellence King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.116418"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010018\u20100180\u2010x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2011.05.668"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.098079"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24119"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7934"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24636"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2012.04.020"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1214136110"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808649105"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00424.2012"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02141"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.494"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2020.04.002"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.01.012"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06969"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.10036"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.058669"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2019.01.020"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30082"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106500"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010024\u201000710\u20106"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592\u2010023\u201001938\u20104"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.20\u20100352"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.204918"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1101\/2025.07.23.666364"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112210"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394311-8.00014-5"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1918167117"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.06.011"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav1898"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.054338"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1001057"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201006176\u20103"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2610"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2025.12.011"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.103468"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201003446\u2010x"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2018.08.011"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02846"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/385257a0"},{"issue":"1","key":"e_1_2_13_43_1","first-page":"12","article-title":"A Newly Discovered Role of Transcription Factors Involved in Pancreas Development and the Pathogenesis of Diabetes Mellitus","volume":"110","author":"Habener J. F.","year":"1998","journal-title":"Proceedings of the Association of American Physicians"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.311339"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2016.12.009"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.059713"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.04.003"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.329763.119"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2023.03.020"},{"issue":"21","key":"e_1_2_13_50_1","first-page":"3630","article-title":"Characterisation of the human Embryonic and Foetal Epicardium during Heart Development","volume":"142","author":"Risebro C. A.","year":"2015","journal-title":"Development (Cambridge, England)"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14221751"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.89377.4"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.194563"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2016.03.014"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.308270"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114092"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh029"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878\u20100261.12366"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003189"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-021-01679-y"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931\u2010019\u20101264\u2010y"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.009308"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2013.07.019"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M206314200"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9738"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e11\u201001\u20100038"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1543960"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2023.07.011"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14916"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201011\u20102614"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085935"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201060934\u20108"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.316100"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44161\u2010023\u201000334\u20107"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.303142"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2019.00030"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201029733\u20103"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01248.2007"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.093385"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.079970"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2021.12.006"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010023\u201001718\u20107"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010021\u201001206\u2010w"},{"key":"e_1_2_13_84_1","article-title":"Molecular Convergence of Risk Variants for Congenital Heart Defects Leveraging a Regulatory Map of the human Fetal Heart","author":"Ma X. R.","year":"2024","journal-title":"medRxiv"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010007\u20106522\u20103"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2349\u201004.2004"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2020.04.006"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44161\u2010022\u201000183\u2010w"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax0249"},{"key":"e_1_2_13_90_1","article-title":"MERFISH+, a Large\u2010Scale, Multi\u2010Omics Spatial Technology Resolves the Molecular Holograms of the 3D human Developing Heart","author":"Kern C.","year":"2025","journal-title":"BioRxiv"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201041279\u20106"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.3390\/jdb2010001"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201035691\u20107"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.252205"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abf2750"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.052928"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.199460"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31924"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.303794"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2020.118806"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13\u2010236828"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.316251"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.3390\/jdb7020007"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2019.12.15"},{"key":"e_1_2_13_105_1","first-page":"1","article-title":"Structure and Function of Mesothelial Cells","volume":"134","author":"Mutsaers S. E.","year":"2007","journal-title":"Cancer Treatment and Research"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.275784"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.12.2397"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1997.8644"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126888"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.3109\/15419061.2011.621561"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a029157"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2015.01.028"},{"key":"e_1_2_13_113_1","article-title":"ATAC Sequencing Protocol","author":"Shapira S.","year":"2021","journal-title":"Protocolsio"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142727.mb2129s109"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010020\u20100439\u2010x"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201045839\u2010z"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb\u20102008\u20109\u20109\u2010r137"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq033"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003118"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20188746"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010021\u201003916\u20105"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giaa151"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.73600.1"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010017\u20101382\u20100"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010016\u20100947\u20107"},{"key":"e_1_2_13_127_1","unstructured":"F. W. T.Kelly Street D.Risso andS.HicksScry: Small\u2010Count Analysis Methods for High\u2010Dimensional Data(2025) https:\/\/bioconductor.org\/packages\/scry."},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.21105\/joss.00861"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201041695\u2010z"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592\u2010023\u201002139\u20109"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592\u2010023\u201002112\u20106"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku365"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.585"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13072\u2010020\u201000342\u2010y"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv145"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abl5197"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.11.028"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592\u2010021\u201001336\u20108"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41540\u2010024\u201000364\u20102"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010014\u20100550\u20108"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010023\u201001716\u20109"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112112"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456\u2010007\u20109085\u2010x"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201003549\u20105"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.08.020"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010019\u20100536\u20102"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2019.07.014"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102551"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00254.2018"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2021\u20100484OC"},{"key":"e_1_2_13_152_1","volume-title":"Stefanpeidli\/mousipy: V0.1.7 (v0.1.7)","author":"Stefan Peidli I.","year":"2025"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmeth.2023.100498"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2021.100141"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010019\u20100068\u20104"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592\u2010024\u201002303\u20109"},{"key":"e_1_2_13_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4463"},{"key":"e_1_2_13_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201050194\u20103"},{"key":"e_1_2_13_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201004520\u2010z"},{"key":"e_1_2_13_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201018035\u20101"},{"key":"e_1_2_13_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102119\u2010x"},{"key":"e_1_2_13_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010021\u201001756\u20104"},{"key":"e_1_2_13_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201058079\u20109"},{"key":"e_1_2_13_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592\u2010021\u201001282\u20105"},{"key":"e_1_2_13_165_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbs017"},{"key":"e_1_2_13_166_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx469"},{"key":"e_1_2_13_167_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163962"},{"key":"e_1_2_13_168_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg540"},{"key":"e_1_2_13_169_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859\u2010019\u20102706\u20108"},{"key":"e_1_2_13_170_1","article-title":"EnhancedVolcano: Publication\u2010Ready Volcano Plots with Enhanced Colouring and Labeling","author":"Kevin Blighe S. R. M. L.","year":"2020","journal-title":"Github"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202517640","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202517640","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202517640","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:55:01Z","timestamp":1783112101000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202517640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,3]]},"references-count":169,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/advs.202517640"],"URL":"https:\/\/doi.org\/10.1002\/advs.202517640","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.08.06.668886","asserted-by":"object"}]},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,3]]},"assertion":[{"value":"2025-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e17640"}}