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While\n                    <jats:italic>Bifidobacterium pseudolongum<\/jats:italic>\n                    (\n                    <jats:italic>B. pseudolongum<\/jats:italic>\n                    ) possesses known probiotic properties, its potential role in protecting against AP has yet to be determined. This study shows that\n                    <jats:italic>B. pseudolongum<\/jats:italic>\n                    alleviates pancreatic damage, inflammation, and apoptosis in mice with caerulein\u2010induced and pancreatic duct ligation\u2010induced AP by enhancing gut barrier function and microbiota diversity. Metabolomics identifies acetate as its key metabolite, and the\n                    <jats:italic>ackA<\/jats:italic>\n                    gene is essential for acetate biosynthesis. Acetate supplementation protects against AP. Mechanistically, acetate acts via GPR43 to inhibit macrophage M1 polarization, and macrophage depletion abrogates this protection. Clinically, the fecal\n                    <jats:italic>B. pseudolongum<\/jats:italic>\n                    abundance is reduced in AP patients and is correlated with disease severity. These findings reveal a microbiota\u2010metabolite\u2010immune axis in AP and highlight the potential of\n                    <jats:italic>B. pseudolongum<\/jats:italic>\n                    and acetate supplementation as novel therapeutic strategies for AP.\n                  <\/jats:p>","DOI":"10.1002\/advs.202517642","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T16:43:33Z","timestamp":1774716213000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>Bifidobacterium Pseudolongum<\/i>\n                    \u2010Derived Acetate Attenuates Acute Pancreatitis Through GPR43\u2010Mediated Suppression of M1 Macrophage Polarization"],"prefix":"10.1002","volume":"13","author":[{"given":"Langyi","family":"Guan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Jiangxi Provincial Key Laboratory of Digestive Diseases Jiangxi Clinical Research Center for 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