{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T10:52:47Z","timestamp":1776941567773,"version":"3.51.4"},"reference-count":69,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82330015"],"award-info":[{"award-number":["82330015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370953"],"award-info":[{"award-number":["82370953"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81991503"],"award-info":[{"award-number":["81991503"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81991500"],"award-info":[{"award-number":["81991500"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFA1801100"],"award-info":[{"award-number":["2023YFA1801100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFA1801104"],"award-info":[{"award-number":["2023YFA1801104"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M742319"],"award-info":[{"award-number":["2023M742319"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A growing consensus indicates that periodontitis (PD) adversely affects glycemic control in type 2 diabetes, though its underlying mechanisms remain unclear. Here, we report that PD, induced by long\u2010term oral ligatures, significantly aggravated hyperglycemia and hepatic gluconeogenesis in high\u2010fat diet\u2010induced obese mice, with its impact on insulin resistance being more pronounced in the liver than in adipose or muscle tissue. Immunologically, PD increased systemic B cell abundance, promoted hepatic B2 cell mobilization, facilitated the expansion of Kupffer cells and adipose tissue macrophages, and activated the NLRP3 inflammasome. Depleting B cells significantly alleviated PD\u2010induced glucose dysregulation, whereas adoptive transfer of B cells from PD mice exacerbated glucose dysregulation and Kupffer cell expansion in\n                    <jats:italic>\n                      Rag1\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice. Mechanistically, upregulation of the interleukin (IL)\u201018 receptor was observed in PD\u2010exposed B cells. IL\u201018 directly enhanced B cell proliferation, and hepatic macrophages from PD mice secreted elevated levels of IL\u201018, further driving B cell expansion. Neutralizing IL\u201018 or depleting macrophages significantly mitigated PD\u2010associated metabolic and B cell abnormalities. Therefore, PD exacerbates hyperglycemia by promoting the pathogenic expansion of B cells and their crosstalk with macrophages via the IL\u201018 signaling axis. Targeting the NLRP3\/IL\u201018 axis holds promise for preventing glucose dysregulation and aberrant immune cell interactions primed by PD.\n                  <\/jats:p>","DOI":"10.1002\/advs.202517653","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T08:17:52Z","timestamp":1773994672000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Periodontitis Induces B Cell\u2010Macrophage Crosstalk to Exacerbate Glucose Dysregulation in Obesity"],"prefix":"10.1002","volume":"13","author":[{"given":"Wen\u2010Zhen","family":"Lin","sequence":"first","affiliation":[{"name":"Department of General Dentistry Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital College of Stomatology, Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u2010Jun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital College of Stomatology, Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Lin","family":"Ye","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, and Institute of Translational Medicine Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases Key Laboratory of Oral Biomedical Research of Zhejiang Province Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital College of Stomatology, Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u2010Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, and Institute of Translational Medicine Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases Key Laboratory of Oral Biomedical Research of Zhejiang Province Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue\u2010Bing","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of General Dentistry Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital College of Stomatology, Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital College of Stomatology, Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Bai","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital College of Stomatology, Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin\u2010Juan","family":"Du","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital College of Stomatology, Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital College of Stomatology, Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, and Institute of Translational Medicine Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases Key Laboratory of Oral Biomedical Research of Zhejiang Province Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, and Institute of Translational Medicine Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases Key Laboratory of Oral Biomedical Research of Zhejiang Province Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Dentistry Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital College of Stomatology, Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Xu","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital College of Stomatology, Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Qian","family":"Meng","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital College of Stomatology, Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo\u2010Cai","family":"Tian","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital College of Stomatology, Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital College of Stomatology, Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu\u2010Chang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital College of Stomatology, Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2010Qin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of General Dentistry Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital College of Stomatology, Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5399-7252","authenticated-orcid":false,"given":"Sheng\u2010Zhong","family":"Duan","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, and Institute of Translational Medicine Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases Key Laboratory of Oral Biomedical Research of Zhejiang Province Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province Hangzhou China"},{"name":"State Key Laboratory of Transvascular Implantation Devices  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.12.012"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.19"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010021\u201000575\u20101"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.12.013"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abn1890"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(05)67728\u20108"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034519857714"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520963710"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010022\u201000825\u20103"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010020\u201000488\u20106"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2023.02.009"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.42693"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.048"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12430"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.106"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513518943"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.03.043"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2013.05.002"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20100716\u20100939\u20102_23"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.80"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.12.025"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.05.010"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010nutr\u2010071812\u2010161113"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010023\u201000857\u2010x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.22012"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010013\u20101486\u2010y"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3791\/61565"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.10.070"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.01.046"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u201012\u2010397933\u20109.00007\u20102"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092\u20108674(92)90030\u2010g"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00289"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104939\u20107837\u20103_23"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102015\u2010309897"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12851"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2021.01.030"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201097868\u20102"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuad018"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010023\u201000848\u2010y"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.189"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.02.028"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.06.012"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.08.002"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.42"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1215840110"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2353"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511305103"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2022.01.003"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/cei\/uxac079"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5052812"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.307166"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14\u20100554"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104789"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201042625\u20104"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.10.009"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062805"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010023\u201001053\u2010w"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010018\u20100054\u20101"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2279"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE\u201007\u20100206"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475\u20102840\u20109\u201011"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.1999.0837"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.12.6880"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106632"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u201012\u2010411619\u20101.00016\u20101"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31755"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201023624\u20109"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.08.009"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202517653","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202517653","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202517653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T10:25:36Z","timestamp":1776939936000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202517653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,20]]},"references-count":69,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/advs.202517653"],"URL":"https:\/\/doi.org\/10.1002\/advs.202517653","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,20]]},"assertion":[{"value":"2025-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e17653"}}