{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:32:16Z","timestamp":1790220736068,"version":"4.1.0"},"reference-count":92,"publisher":"Wiley","issue":"32","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Acquired tick resistance (ATR) is well characterized in tick\u2010exposed animals, compromising tick fitness through antibody\u2010mediated activation of basophils. Yet, anti\u2010tick vaccines inducing ATR have had limited success. Here, we describe a neuroimmune event preceding ATR that leads to rapid host\u2010mediated tick removal. Tick\u2010sensitized guinea pigs mechanically remove ticks within 3\u20136\u00a0h via an acquired neuroimmune\u2010induced itch response that correlates with increased dermal expression of itch\u2010associated genes and skin infiltration by CD3\n +<\/jats:sup>\n T cells and Iba\u20101\n +<\/jats:sup>\n macrophages, independent of IgG and IgE antibodies. Inhibiting the development of acquired T cell memory by averting naive lymphocyte egress from lymph nodes with the sphingosine\u20101\u2010phosphate receptor modulator FTY720, before tick sensitization, prevents Iba\u20101\n +<\/jats:sup>\n macrophage and CD3\n +<\/jats:sup>\n T cell infiltration to the tick bite site and abrogates scratching and tick removal. This neuroimmune response is independent of Trpv1 as tick\u2010sensitized guinea pigs treated with the Trpv1 agonist, resiniferatoxin, remove ticks effectively. Strikingly, prior exposure to a single tick is sufficient to generate a fast and active itch\u2010induced tick removal (IITR) that is observed even in tick\u2010attached sites distant from the location of previous tick exposure. IITR represents a novel approach to tick\u2010borne disease prevention through early tick detection and fast removal.\n <\/jats:p>","DOI":"10.1002\/advs.202517742","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:42:13Z","timestamp":1769517733000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9374-6706","authenticated-orcid":false,"given":"Johannes S. 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