{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:37:34Z","timestamp":1791394654598,"version":"4.3.3"},"reference-count":67,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ammonia\u2010induced T lymphocyte death (AITD) offers a new perspective on immune regulation after the activation of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. However, the use of a single AITD inhibitor is constrained by multiple factors in the immunosuppressive tumor microenvironment and requires combination strategies to achieve breakthroughs. Herein, a rationally designed organic nanozyme (IR\u2010IHpd) is presented, integrating anthocyanin\u2010based near\u2010infrared photodynamic therapy (NIR\u2010PDT) and Hemin\u2010derived peroxidase (POD)\u2010like catalytic activity. Under 780\u00a0nm laser irradiation, it generates ROS through Type I\/II photodynamic mechanisms while catalyzing H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    into cytotoxic \u00b7OH, establishing an uninterrupted ROS generation. Co\u2010encapsulated with CB\u2010839 in DSPE\u2010Hyd\u2010PEG and coated with dendritic cell (DC) membranes to form a biomimetic system (DMIC), this system targets both tumors and T cells. After intravenous administration, the DMIC nanozyme system efficiently accumulates in tumor tissues, tumor\u2010draining lymph nodes, and spleens, where NIR irradiation induces tumor immunogenic cell death while promoting DCs maturation and T cell activation. The DMIC also functions as a tumor vaccine, capable of directly activating T cells and preventing tumor occurrence. Furthermore, the released CB\u2010839 reduces intracellular ammonia levels in T cells, thereby enhancing anti\u2010tumor immunity. This pioneering work achieves targeted AITD inhibition for the first time, integrating NIR\u2010PDT, metabolic modulation, and immune activation to advance nanozyme\u2010based immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.202518037","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T12:22:46Z","timestamp":1762518166000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Biomimetic Organic Nanozyme as Tumor Vaccines for Targeted Suppression of Ammonia\u2010Induced T Lymphocyte Death to Augment Breast Cancer Immunotherapy"],"prefix":"10.1002","volume":"13","author":[{"given":"Meng","family":"Suo","sequence":"first","affiliation":[{"name":"Research Center of Nanomedicine Technology The Second Affiliated Hospital of Guangxi Medical University  Nanning 530000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Harbin Medical University Cancer Hospital  150 Haping Road Harbin 150081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingpu","family":"Yang","sequence":"additional","affiliation":[{"name":"Research Center of Nanomedicine Technology The Second Affiliated Hospital of Guangxi Medical University  Nanning 530000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Center of Nanomedicine Technology The Second Affiliated Hospital of Guangxi Medical University  Nanning 530000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center of Nanomedicine Technology The Second Affiliated Hospital of Guangxi Medical University  Nanning 530000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1375-6539","authenticated-orcid":false,"given":"Daoming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor Nanfang Hospital Southern Medical University  Guangzhou Guangdong 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Breast Radiotherapy Harbin Medical University Cancer Hospital  Harbin Heilongjiang 150081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanni","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Harbin Medical University Cancer Hospital  150 Haping Road Harbin 150081 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