{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:09:09Z","timestamp":1773011349737,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Systemic infections of\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    are dire, with a mortality rate reaching 60%. The transformation between the yeast and hyphae states of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    resists existing medications and the body's immune defenses. Some currently available drugs only inhibit the growth of the yeast\u2010form of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    . Therefore, a synthetic lethal therapy that leverages the dimorphism of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    is developed. This therapy utilizes rapamycin to eliminate yeast\u2010like\n                    <jats:italic>C. albicans<\/jats:italic>\n                    through the mammalian target of rapamycin pathway. Simultaneously, deferasirox restricts iron resources, thereby inhibiting polarization and hyphae formation. As a result,\n                    <jats:italic>C. albicans<\/jats:italic>\n                    cannot evade the lethal effects of drugs and immune cells by undergoing morphological transformations. Furthermore, inspired by the recognition process of fungi by macrophages, macrophage membranes with high expression of dectin\u20101 are utilized to deliver rapamycin and deferasirox. The synthetic lethal therapy based on dimorphism significantly improves the survival rate of mice with systemic infections, thereby offering a promising strategy for treating drug\u2010resistant\n                    <jats:italic>C. albicans<\/jats:italic>\n                    infections.\n                  <\/jats:p>","DOI":"10.1002\/advs.202518196","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T08:57:59Z","timestamp":1764752279000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthetic Lethal Therapy Based on Dimorphism for Systemic Infection of Drug\u2010Resistant\n                    <i>Candida albicans<\/i>"],"prefix":"10.1002","volume":"13","author":[{"given":"Yang","family":"Gao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Microbial Technology School of Food and Pharmaceutical Engineering Nanjing Normal University  Nanjing 210023 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