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Here, we present a preclinical investigation of nanocellulose as a gut microbiota\u2010targeted dietary intervention to restore bile acid homeostasis. We demonstrate that nanocellulose, particularly cellulose nanofibers (CNF), administered prophylactically, attenuated maternal TBA and improved offspring survival in a rat ICP model by enriching probiotic microbial taxa while suppressing bile acid\u2010transforming bacteria. These microbial shifts promoted the accumulation of fecal primary bile acids and activation of gut\u2013liver farnesoid X receptor (FXR) signaling. This cascade reduced intestinal reabsorption and hepatic synthesis of bile acids while promoting their excretion in feces. Collectively, pre\u2010gestational CNF effectively lowered systemic bile acid burden and mitigated the ICP phenotype. 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