{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:29:45Z","timestamp":1786634985580,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"45","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81922077"],"award-info":[{"award-number":["81922077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4\n                    <jats:sup>+<\/jats:sup>\n                    regulatory T\u2010cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration. However, the mechanisms by which Tregs protect against diabetic vascular disease remain unclear. Here, we demonstrate that endothelial cells (ECs) upregulate the transcription factor YY1 during post\u2010ischemic vascular regeneration, but this response is blunted in diabetic ECs. Endothelial\u2010specific deletion of YY1 leads to defective vascular regeneration following ischemia. Mechanistically, YY1 binds to the\n                    <jats:italic>MAML1<\/jats:italic>\n                    promoter at regions enriched for H3K4me3 and H3K27ac. YY1 activates\n                    <jats:italic>MAML1<\/jats:italic>\n                    transcription, likely by recruiting H3K4me3 writers (SETD1A, MLL1, MLL2) and their scaffold WDR5 within the COMPASS complex, together with the H3K27ac writer p300. Functionally, Tregs enhance vascular regeneration through paracrine signaling even in T2D mice. Adoptive Treg transfer restores regenerative capacity by reactivating the endothelial YY1\/MAML1 axis. These findings identify a Treg\u2010YY1\u2010MAML1 pathway as a key regulator of endothelial function and vascular repair, offering mechanistic insight into how Tregs promote tissue regeneration in diabetes\u2010associated microvascular dysfunction.\n                  <\/jats:p>","DOI":"10.1002\/advs.202518564","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T12:52:46Z","timestamp":1779281566000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CD4\n                    <sup>+<\/sup>\n                    Tregs Drive Post\u2010Ischemic Sprouting Angiogenesis via Endothelial YY1\/MAML1 Reactivation"],"prefix":"10.1002","volume":"13","author":[{"given":"Hang","family":"Qu","sequence":"first","affiliation":[{"name":"CAS CEMCS\u2010CUHK Joint Laboratory for Cardiovascular Sciences Department of Chemical Pathology and Li Ka Shing Institute of Health Science The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng Kiu","family":"Ho","sequence":"additional","affiliation":[{"name":"CAS CEMCS\u2010CUHK Joint Laboratory for Cardiovascular Sciences Department of Chemical Pathology and Li Ka Shing Institute of Health Science The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitao","family":"Liu","sequence":"additional","affiliation":[{"name":"CAS CEMCS\u2010CUHK Joint Laboratory for Cardiovascular Sciences Department of Chemical Pathology and Li Ka Shing Institute of Health Science The Chinese University of Hong Kong  Hong Kong China"},{"name":"Department of Surgery Faulty of Medicine Prince of Wales Hospital The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Cui","sequence":"additional","affiliation":[{"name":"CAS CEMCS\u2010CUHK Joint Laboratory for Cardiovascular Sciences Department of Chemical Pathology and Li Ka Shing Institute of Health Science The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangfeng","family":"Hou","sequence":"additional","affiliation":[{"name":"CAS CEMCS\u2010CUHK Joint Laboratory for Cardiovascular Sciences Department of Chemical Pathology and Li Ka Shing Institute of Health Science The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai","family":"Liang","sequence":"additional","affiliation":[{"name":"CAS CEMCS\u2010CUHK Joint Laboratory for Cardiovascular Sciences Department of Chemical Pathology and Li Ka Shing Institute of Health Science The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchu","family":"Ye","sequence":"additional","affiliation":[{"name":"CAS CEMCS\u2010CUHK Joint Laboratory for Cardiovascular Sciences Department of Chemical Pathology and Li Ka Shing Institute of Health Science The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randolph H. L.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Surgery Faulty of Medicine Prince of Wales Hospital The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Hori","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Microbiology Graduate School of Pharmaceutical Sciences The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhou","sequence":"additional","affiliation":[{"name":"CAS CEMCS\u2010CUHK Joint Laboratory for Cardiovascular Sciences New Cornerstone Science Laboratory Key Laboratory of Multi\u2010Cell Systems Shanghai Institute of Biochemistry and Cell Biology Center for Excellence in Molecular Cell Science Chinese Academy of Sciences  Shanghai 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