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We observed reduced\n                    <jats:italic>Bifidobacterium breve<\/jats:italic>\n                    (\n                    <jats:italic>B. breve<\/jats:italic>\n                    ) abundance in AD patients. A new\n                    <jats:italic>B. breve<\/jats:italic>\n                    strain was isolated from human stools and nomenclated as\n                    <jats:italic>Yang08<\/jats:italic>\n                    . In MC903\u2010induced AD\u2010like mouse models,\n                    <jats:italic>Yang08<\/jats:italic>\n                    outperformed a standard strain, ameliorating disease severity, including reduced ear thickening, epidermal hyperplasia, and mast cell infiltration in a manner dependent on viable bacteria and an intact gut microbiota. Antibiotic\u2010mediated microbiota depletion abrogated its efficacy, while fecal microbiota transfer from\n                    <jats:italic>Yang08<\/jats:italic>\n                    \u2010treated mice conferred protection, confirming microbial remodeling as essential. Metagenomics revealed\n                    <jats:italic>Yang08<\/jats:italic>\n                    specifically enriched\n                    <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    , which was required for therapeutic effects in germ\u2010free mice. Mechanistically,\n                    <jats:italic>Yang08<\/jats:italic>\n                    abolished both neutrophil influx and NET deposition in lesions, with ex vivo experiments showing blunted NETosis capacity. Its therapeutic benefits were reversed by neutrophil depletion, NET degradation, or PAD4 inhibition. Overall,\n                    <jats:italic>Yang08<\/jats:italic>\n                    alleviates AD by enriching\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    and inhibiting skin NETosis, emerging as a promising prophylactic candidate prevention for AD prevention.\n                  <\/jats:p>","DOI":"10.1002\/advs.202518588","type":"journal-article","created":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T18:27:02Z","timestamp":1770575222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Bifidobacterium Breve Yang08<\/i>\n                    Alleviates Atopic Dermatitis By Enriching Akkermansia Muciniphila and Inhibiting Neutrophil Extracellular Traps Formation In Mice"],"prefix":"10.1002","volume":"13","author":[{"given":"Yanqiang","family":"Shi","sequence":"first","affiliation":[{"name":"Dermatology Hospital Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"He","sequence":"additional","affiliation":[{"name":"Dermatology Hospital Southern Medical University  Guangzhou China"},{"name":"The First School of Clinical Medicine, Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengyi","family":"Li","sequence":"additional","affiliation":[{"name":"Dermatology Hospital Southern Medical University  Guangzhou China"},{"name":"The First School of Clinical Medicine, Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung","family":"Chan","sequence":"additional","affiliation":[{"name":"Dermatology Hospital Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Dermatology Hospital Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7155-6079","authenticated-orcid":false,"given":"Bin","family":"Yang","sequence":"additional","affiliation":[{"name":"Dermatology Hospital Southern Medical University  Guangzhou China"},{"name":"The First School of Clinical Medicine, Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0814-6322","authenticated-orcid":false,"given":"Qing","family":"Li","sequence":"additional","affiliation":[{"name":"Dermatology Hospital Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31286-1"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2023911"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2025.01.013"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2024.03.006"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02519-4"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-021-08880-3"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens11060642"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.70136"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/imt2.270"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16372"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/27697061.2023.2232021"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13836"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111867"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-024-09004-3"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.06.044"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v103.13382"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.48448"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2023.109805"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15794"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-329543"},{"key":"e_1_2_12_22_1","first-page":"100","author":"Lau H. 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