{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:58:10Z","timestamp":1773835090705,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571050"],"award-info":[{"award-number":["82571050"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071079"],"award-info":[{"award-number":["82071079"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31701126"],"award-info":[{"award-number":["31701126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300682"],"award-info":[{"award-number":["82300682"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["18JCQNJC82300"],"award-info":[{"award-number":["18JCQNJC82300"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2025206179"],"award-info":[{"award-number":["H2025206179"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Osteogenic differentiation is essential for bone remodeling and repair. Protein arginine methyltransferases (PRMTs) regulate this process; however, their key substrates and mechanisms remain elusive. Here, we identify TEAD3, a TEA domain transcription factor mediating Hippo signaling output, as an arginine\u2010methylated regulator of periodontal ligament stem cells (PDLSCs) osteogenesis. Mechanistically, TEAD3 is methylated at arginine 55 (R55), a conserved residue within its DNA\u2013binding TEA domain. Disruption of R55 methylation via R55K mutation enhances formation of TEAD3 homodimer condensates, which spatially constrain RUNX2 transcriptional activity without disrupting its Hippo signaling functions. Notably, the TEAD3\u2010R55K mutant exhibits heightened sensitivity to TEAi, a TEA domain\u2010 targeting inhibitory peptide. These findings unveil arginine methylation as a critical switch governing TEAD3\u2010mediated osteogenic commitment and highlight TEAD\u2010targeted strategies as promising therapeutics for bone regeneration.<\/jats:p>","DOI":"10.1002\/advs.202518597","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T12:12:19Z","timestamp":1768911139000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Arginine Methylation Antagonizes TEAD3\u2010Mediated Repression to Promote Osteogenic Differentiation by Disrupting RUNX2\u2010Sequestrating Condensates"],"prefix":"10.1002","volume":"13","author":[{"given":"Lei","family":"Cao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Experimental Hematology The Province and Ministry Co\u2010sponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease (Ministry of Education) Tianjin Key Laboratory of Medical Epigenetics Department of Endodontics Tianjin Medical University School and Hospital of Stomatology &amp; Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration Tianjin Medical University  Tianjin China"},{"name":"Department of Cell Biology Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruohui","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology The Province and Ministry Co\u2010sponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease (Ministry of Education) Tianjin Key Laboratory of Medical Epigenetics Department of Endodontics Tianjin Medical University School and Hospital of Stomatology &amp; Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration Tianjin Medical University  Tianjin China"},{"name":"Department of Pediatric Dentistry Hospital of Stomatology and Hebei Provincial Key Laboratory of Stomatology Hebei Medical University  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology The Province and Ministry Co\u2010sponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease (Ministry of Education) Tianjin Key Laboratory of Medical Epigenetics Department of Endodontics Tianjin Medical University School and Hospital of Stomatology &amp; Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration Tianjin Medical University  Tianjin China"},{"name":"Department of Cell Biology Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaofei","family":"Tao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology The Province and Ministry Co\u2010sponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease (Ministry of Education) Tianjin Key Laboratory of Medical Epigenetics Department of Endodontics Tianjin Medical University School and Hospital of Stomatology &amp; Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xudong","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology The Province and Ministry Co\u2010sponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease (Ministry of Education) Tianjin Key Laboratory of Medical Epigenetics Department of Endodontics Tianjin Medical University School and Hospital of Stomatology &amp; Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration Tianjin Medical University  Tianjin China"},{"name":"Department of Cell Biology Tianjin Medical University  Tianjin China"},{"name":"International Science and Technology Cooperation Base of Spinal Cord Injury Department of Orthopedic Surgery Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8511-2658","authenticated-orcid":false,"given":"Dayong","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology The Province and Ministry Co\u2010sponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease (Ministry of Education) Tianjin Key Laboratory of Medical Epigenetics Department of Endodontics Tianjin Medical University School and Hospital of Stomatology &amp; Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration Tianjin Medical University  Tianjin China"},{"name":"Department of Pediatric Dentistry Hospital of Stomatology and Hebei Provincial Key Laboratory of Stomatology Hebei Medical University  Shijiazhuang China"},{"name":"Shanghai Engineering Research Center of Tooth Restoration and Regeneration &amp; Tongji Research Institute of Stomatology &amp; Department of Endodontics Shanghai Tongji Stomatological Hospital and Dental School Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1096\/fba.2020-00058"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40204-019-00125-z"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-025-04288-4"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12250"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01134-4"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.09.004"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2019.0025"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2022.04.001"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12009"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-025-04777-6"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80258-5"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80260-3"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80259-7"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80257-3"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.04.010"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-97217-7"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-59346-5"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1664408"},{"key":"e_1_2_10_20_1","article-title":"SUMOylation of TEAD1 Modulates the Mechanism of Pathological Cardiac Hypertrophy","author":"Shi X.","year":"2024","journal-title":"Advancement of Science"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad1124"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15301-0"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba4147"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0070-z"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3876"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00159-8"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.7.1563"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2016.03.008"},{"key":"e_1_2_10_29_1","article-title":"Targeting the TEA DNA Binding Domain of TEAD with a Peptide Inhibitor TEAi Suppresses Oncogenic Transcription and Tumor Growth","author":"Cao L.","year":"2025","journal-title":"BioRxiv"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2542"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.864191"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49045-y"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12413"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29780"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13551"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2018.05.001"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2018.08.025"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1815-7"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1369"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202403177"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0134-x"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1247625"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-022-03628-7"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021431"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku705"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202518597","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202518597","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202518597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T08:52:02Z","timestamp":1773823922000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202518597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,20]]},"references-count":44,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/advs.202518597"],"URL":"https:\/\/doi.org\/10.1002\/advs.202518597","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,20]]},"assertion":[{"value":"2025-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e18597"}}