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Here, we present a microgel\u2010based modular fabrication strategy to engineer programmable hierarchically porous microgel\u2010based hydrogel patches (HPMPs). This strategy generates porous microgels with adjustable porosity and bio\/cytocompatibility via gas\u2010shearing microfluidics integrated with an aqueous two\u2010phase system, exhibiting precise model structural fidelity, synergistic tissue adhesion, and architectural resilience. Additionally, the interconnected hierarchical porous structure of HPMP enables rapid formation of functional vascular networks in vitro. To demonstrate the broad biomedical applicability of our modular bioprinting platform, we implemented this strategy in myocardial infarction treatment. We successfully validated the application\u2010driven requirements via iPSC\u2010laden porous microgels directing cardiomyocyte differentiation and functional maturity. HPMP with Janus\u2010structured unilateral adhesiveness is conducive to preventing chest adhesions and cellular unilateral proliferation, migration, and angiogenesis in vivo. This microgel\u2010based modular fabrication strategy establishes a promising platform for targeted cardiac repair, further promoting the development of tissue engineering and regenerative medicine.<\/jats:p>","DOI":"10.1002\/advs.202518646","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T10:50:36Z","timestamp":1767610236000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Microgel\u2010Based Hierarchical Porous Hydrogel Patch with Adhesion and Resilience for Myocardial Infarction"],"prefix":"10.1002","volume":"13","author":[{"given":"Ziyang","family":"Liu","sequence":"first","affiliation":[{"name":"Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target &amp; Clinical Pharmacology the NMPA and State Key Laboratory of Respiratory Disease School of Pharmaceutical Sciences Guangzhou Medical University  Guangzhou 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