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Under physiological conditions, it acts as a dynamic scaffold, interacting with monocarboxylate transporters (MCTs), integrins, and cyclophilin A (CyPA) to orchestrate spermatogenesis, embryo implantation, and neural network function. Pathological overexpression of CD147 induces the secretion of matrix metalloproteinases (MMPs), epithelial\u2010mesenchymal transition (EMT), metabolic reprogramming, and immune evasion, functioning as an independent prognostic biomarker in multiple malignancies. Beyond oncology, CD147 is exploited as an entry receptor for pathogens, including SARS\u2011CoV\u20112, HIV\u20111,\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    , and contributes mechanistically to cardiovascular, autoimmune, and neurodegenerative diseases. Notably, CD147 acts as a fundamental \u201cEnergy\u2010Structure Coupler,\u201d coordinating metabolic flux (via MCTs) with morphogenetic plasticity (via integrins\/MMPs) to maintain cellular homeostasis. This review summarizes current insights into CD147's molecular structure, isoforms, post\u2010translational modifications, and signaling pathways, highlighting its pivotal roles across cancer, infection, autoimmunity, and cardiovascular disease. Finally, we discuss challenges such as the \u201cspecificity paradox\u201d and propose emerging strategies to exploit CD147 as a precision biomarker and therapeutic target across diverse diseases.\n                  <\/jats:p>","DOI":"10.1002\/advs.202518884","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T09:52:39Z","timestamp":1766829159000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["CD147\/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0259-4944","authenticated-orcid":false,"given":"Xiang\u2010Min","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Cell Biology National Translational Science Center for Molecular Medicine The Fourth Military Medical University Xi'an, Shaanxi 710032 China"},{"name":"State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Xi'an, Shaanxi 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4690-4622","authenticated-orcid":false,"given":"Huijie","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Cell Biology National Translational Science Center for Molecular Medicine The Fourth Military Medical University Xi'an, Shaanxi 710032 China"},{"name":"State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Xi'an, Shaanxi 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5512-4623","authenticated-orcid":false,"given":"Zhi\u2010Nan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cell Biology National Translational Science Center for Molecular Medicine The Fourth Military Medical University Xi'an, Shaanxi 710032 China"},{"name":"State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Xi'an, Shaanxi 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,27]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u2010291x(82)92042\u20103"},{"issue":"13","key":"e_1_2_13_3_1","first-page":"3154","article-title":"Tumor Cell\u2010Derived Collagenase\u2010Stimulatory Factor Increases Expression of Interstitial Collagenase, Stromelysin, and 72\u2010kDa Gelatinase","volume":"53","author":"Kataoka H.","year":"1993","journal-title":"Cancer Research"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523\u20101747.ep12348959"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000133573"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a123045"},{"issue":"2","key":"e_1_2_13_7_1","first-page":"434","article-title":"The human Tumor Cell\u2010Derived 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