{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:54:37Z","timestamp":1781535277551,"version":"3.54.5"},"reference-count":60,"publisher":"Wiley","issue":"30","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52473279,52303205,81972547."],"award-info":[{"award-number":["52473279,52303205,81972547."]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tumor\u2010associated bone invasion often occurs in aggressive tumors and strongly compromises the efficacy of tumor treatment, which makes it challenging for comprehensive tumor therapy, highlighting the importance of simultaneous tumor elimination and tumor\u2010associated osteolysis restoration. To achieve this goal, this study reports a versatile nanohybrid (CaO\n                    <jats:sub>2<\/jats:sub>\n                    @CuMOF@HAP) synthesized by coating bimetallic nanoclusters (CaO\n                    <jats:sub>2<\/jats:sub>\n                    @CuMOF) with osteogenic growth peptide (OGP)\u2010modified hyaluronic acid (HAP) for high\u2010performance oncotherapy. On\u2010demand sequential release is realized in specific tumor environments, where OGP can be released into matrix metalloproteinase\u20109 (MMP9)\u2010enriched tumor extracellular space through cleavage of the MMP9\u2010responsive linker between OGP and HA, and dual ions (Cu\n                    <jats:sup>2+<\/jats:sup>\n                    and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ) are liberated via pH\u2010triggered decomposition of the nanohybrid following tumor cell internalization. On the basis of this, small\u2010sized OGP could penetrate into deep\u2010seated, tumor\u2010involved, bone areas for promoting effective osteogenesis, while the excessive ions in targeted tumor cells synergistically disrupted intracellular ion homeostasis for effective metal ion interference therapy. Having killed tumor cells and promoted osteogenesis, CaO\n                    <jats:sub>2<\/jats:sub>\n                    @CuMOF@HAP exhibited highly efficient antitumor effects on an orthotopic oral squamous cell carcinoma tumor\u2010bearing mouse model with mandibular bone invasion. Without cytotoxic drugs, this nanohybrid circumvents drug resistance and nonspecific toxicity, offering excellent biocompatibility and high antitumor efficiency for clinical application.\n                  <\/jats:p>","DOI":"10.1002\/advs.202518962","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:06:09Z","timestamp":1773824769000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Dual\u2010Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor\u2010Associated Osteolysis Restoration via Sequential Release"],"prefix":"10.1002","volume":"13","author":[{"given":"Lan","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration Hubei Key Laboratory of Stomatology Key Laboratory of Oral Biomedicine Ministry of Education School &amp; Hospital of Stomatology Wuhan University  Wuhan P. 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