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This study identifies a conserved regulatory hub in the human pathogen\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    , where the RNA\u2010binding protein (RBP) CsdA interacts with the global regulator LaeB in the nucleus to regulate biosynthesis of the secondary metabolite fumiquinazoline C (FqC). Disruption of the CsdA\u2010LaeB interaction hyperactivates FqC production, enhancing fungal colonization and lethality in murine invasive aspergillosis models. Integrative metabolomic and transcriptomic analyses reveal that CsdA and LaeB function as co\u2010regulators of a broader secondary metabolic gene cluster network, with FqC emerging as an effector that mediates virulence in vivo. Genetic validation confirms that FqC is strictly required for the increased virulence phenotype of CsdA\u2010 or LaeB\u2010deficient strains, while analyses of clinical isolates demonstrate a striking inverse correlation: reduced CsdA and LaeB expression coincides with elevated FqC production, showing consistency with the infection outcomes of the deletion mutants. This work identifies the RBP\u2010based interaction that regulates fungal metabolic virulence, shedding new light on the post\u2010transcriptional regulatory logic linking secondary metabolism to pathogenicity and offering alternative strategies for diagnostic development and therapeutic intervention in invasive fungal diseases.\n                  <\/jats:p>","DOI":"10.1002\/advs.202519021","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T14:42:48Z","timestamp":1767796968000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["CsdA\u2010LaeB Regulatory Hub Contributes to\n                    <i>Aspergillus fumigatus<\/i>\n                    Virulence via Fumiquinazoline C 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