{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:37:13Z","timestamp":1790044633916,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22577102"],"award-info":[{"award-number":["22577102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The full\u2010component utilization of lignocellulosic biomass under mild conditions remains a formidable challenge for both biocatalytic systems and industrial processes. Herein, we report a Lewis pair engineering strategy to construct a defective Cu\u2010doped Mn oxide nanozyme (D\u2010CuMnO\n                    <jats:sub>x<\/jats:sub>\n                    ) featuring the simultaneous introduction of manganese and oxygen vacancies. The resulting undercoordinated Mn sites act as Lewis acids to activate glycosidic bonds, while adjacent oxygen species serve as Lewis bases to promote nucleophilic attack and electron transfer, thereby collectively lowering the energy barriers for both hydrolytic and oxidative reactions. As a consequence, D\u2010CuMnO\n                    <jats:sub>x<\/jats:sub>\n                    exhibits an approximately fourfold enhancement in glycosidase activity and markedly improved cold\u2010adapted performance compared with oxygen\u2010vacancy\u2010only CuMnO\n                    <jats:sub>x<\/jats:sub>\n                    , while simultaneously maintaining robust oxidase\u2010like activity. Benefiting from these advantages, D\u2010CuMnO\n                    <jats:sub>x<\/jats:sub>\n                    serves as a cooperative hydrolytic\u2010oxidative platform that enables the depolymerization of cellulose and hemicellulose alongside the oxidative cleavage of lignin, thereby achieving simultaneous degradation of the major components in raw corn stalks under mild and low\u2010temperature conditions. This work establishes Lewis pair engineering as a versatile strategy for the rational design of multifunctional cold\u2010adapted nanozymes and highlights their considerable potential for sustainable biomass valorization.\n                  <\/jats:p>","DOI":"10.1002\/advs.202519235","type":"journal-article","created":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T11:50:09Z","timestamp":1771156209000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lewis Pair\u2010Engineered CuMnO\n                    <sub>x<\/sub>\n                    as Cold\u2010Adapted Multinanozyme for Cooperative Hydrolytic and Oxidative Degradation of Raw Corn Stalk"],"prefix":"10.1002","volume":"13","author":[{"given":"Huile","family":"Liu","sequence":"first","affiliation":[{"name":"School of Life Sciences and Technology Northwestern Polytechnical University  Xi'an China"},{"name":"Nanozyme Laboratory in Zhongyuan Henan Academy of Innovations in Medical Science  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Di","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Technology Northwestern Polytechnical University  Xi'an China"},{"name":"Nanozyme Laboratory in Zhongyuan Henan Academy of Innovations in Medical Science  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Technology Northwestern Polytechnical University  Xi'an China"},{"name":"Nanozyme Laboratory in Zhongyuan Henan Academy of Innovations in Medical Science  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Technology Northwestern Polytechnical University  Xi'an China"},{"name":"Nanozyme Laboratory in Zhongyuan Henan Academy of 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