{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:00:55Z","timestamp":1791644455365,"version":"4.3.4"},"reference-count":60,"publisher":"Wiley","issue":"26","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272804"],"award-info":[{"award-number":["82272804"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91959114"],"award-info":[{"award-number":["91959114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872106"],"award-info":[{"award-number":["81872106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["22JCQNJC01700"],"award-info":[{"award-number":["22JCQNJC01700"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The immunosuppressive tumor microenvironment (TME) promotes resistance to radiation therapy, substantially limiting the efficacy of radioimmunotherapy. Here, we report a hyaluronic acid (HA)\u2010coated manganese\u2013platinum (MnPt) bimetallic nanozyme (HD@MnO\n                    <jats:sub>2<\/jats:sub>\n                    ) that integrates enzymatic cascade initiation with cGAS\u2013STING pathway activation to facilitate radioimmunotherapy for breast cancer treatment. The HD@MnO\n                    <jats:sub>2<\/jats:sub>\n                    features a cationic MnO\n                    <jats:sub>2<\/jats:sub>\n                    core sequentially modified with HA and cisplatin, enabling CD44\u2010targeted delivery and improved biocompatibility. Leveraging the reversible valence cycling of Mn and Pt in the TME, HD@MnO\n                    <jats:sub>2<\/jats:sub>\n                    offers multienzyme\u2010like activity, which collectively enhances H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    utilization, depletes glutathione, and promotes O\n                    <jats:sub>2<\/jats:sub>\n                    generation. These cascade reactions combined with radiotherapy effectively trigger bursts of ROS production, disrupt redox homeostasis, and induce immunogenic cell death. Concurrently, released Mn\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    activates the cGAS\u2013STING pathway, thereby boosting innate immunity. The combination of these effects promotes dendritic cell maturation and increases CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell infiltration, thereby establishing a radiotherapy\u2010immune mutual amplification loop. Both in vitro and in vivo experiments demonstrated that HD@MnO\n                    <jats:sub>2<\/jats:sub>\n                    markedly eliminates primary tumors and suppresses metastatic tumors by overcoming radioresistance and eliciting potent systemic antitumor immunity. Overall, this approach offers a promising strategy for addressing the conventional limitations of radioimmunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.202519300","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T04:47:08Z","timestamp":1773377228000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Engineering MnPt Bimetallic Nanozymes for Cascade Enzymatic Therapy and Enhanced Radio\u2010Immunotherapy"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9641-4248","authenticated-orcid":false,"given":"Wenyi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology The Second Hospital of Tianjin Medical University  Tianjin China"},{"name":"Tianjin Institute of Urology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Hospital of Tianjin Medical University  Tianjin China"},{"name":"Tianjin Institute of Urology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Hospital of Tianjin Medical University  Tianjin China"},{"name":"Tianjin Institute of Urology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luhaoxiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Hospital of Tianjin Medical University  Tianjin China"},{"name":"Department of Gastroenterology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Hospital of Tianjin Medical University  Tianjin China"},{"name":"Tianjin Institute of Urology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Hospital of Tianjin Medical University  Tianjin China"},{"name":"Tianjin Institute of Urology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Hospital of Tianjin Medical University  Tianjin China"},{"name":"Tianjin Institute of Urology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Urology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4656-172X","authenticated-orcid":false,"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Hospital of Tianjin Medical University  Tianjin China"},{"name":"Tianjin Institute of Urology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202003338"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010020\u20100150\u2010x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(21)00233\u20106"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010022\u201001341\u20100"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.22.01751"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.0249"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010025\u201003571\u2010z"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2021.13171"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.844142"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2022.14"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.12659\/msm.934116"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010018\u20100758\u20107"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201024902\u20102"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201018745\u20106"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202417370"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c10352"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43556\u2010024\u201000184\u20100"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1cs01145f"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.9b00171"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1088878"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10498"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202501746"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.4c00817"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c05483"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202401576"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202511181"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202509994"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202505911"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.0c00396"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122660"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201023737\u20101"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c09293"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202307858"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201033301\u20100"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b06111"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010021\u201000962\u20109"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10010013"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010024\u201001239\u2010x"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.73039"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c05324"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123407"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2017.11.005"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c15115"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202210144"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adq3870"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201057190\u20101"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c12343"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202403107"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S474098"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201050416\u20108"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001955\u20105"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201045307\u2010x"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010024\u201006644\u20103"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13271"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423\u2010023\u201000990\u20106"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.08.014"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201051411\u20109"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423\u2010024\u201001167\u20105"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S510514"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201049825\u20106"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202519300","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202519300","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202519300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:06:24Z","timestamp":1784304384000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202519300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,12]]},"references-count":60,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/advs.202519300"],"URL":"https:\/\/doi.org\/10.1002\/advs.202519300","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,12]]},"assertion":[{"value":"2025-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e19300"}}