{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:26:44Z","timestamp":1783114004974,"version":"3.54.6"},"reference-count":34,"publisher":"Wiley","issue":"37","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201023"],"award-info":[{"award-number":["82201023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Anthracyclines such as doxorubicin (DOX) are widely used in cancer chemotherapy but their clinical utility is severely limited by cumulative, dose\u2010dependent, and largely irreversible cardiotoxicity. Mounting evidence suggests that DOX disrupts intestinal barrier integrity and microbial homeostasis, aggravating systemic oxidative stress and accelerating myocardial injury through the gut\u2013heart axis. Probiotics offer a potential strategy to stabilize the intestinal microenvironment, yet their fragile nature and poor survival in the gastrointestinal tract hinder clinical translation. Here, we present an orally administrable bioinspired peroxisome engineered probiotic (BPEP) as a safe and effective therapeutic platform. Ruthenium\u2010based nanozymes with superoxide dismutase\u2010like and catalase\u2010like activities were encapsulated in a lipid shell to form bioinspired peroxisomes (BP) and covalently anchored onto\n                    <jats:italic>Escherichia coli Nissle 1917<\/jats:italic>\n                    . The lipid shell enhances probiotic resistance to gastric acid, bile salts, and reactive oxygen species, improving gastrointestinal survival and colonization. Acting as a living carrier, probiotics deliver BPs to the intestinal barrier, where they synergistically scavenge reactive oxygen and nitrogen species, restore tight junction integrity, and remodel microbial communities. In a chronic DOX\u2010induced cardiotoxicity mouse model, oral administration of BPEP effectively alleviated oxidative stress, preserved intestinal barrier function, stabilized microbial homeostasis, and ultimately improved cardiac function. This work establishes a bioinspired probiotic\u2010nanozyme hybrid strategy that overcomes the intrinsic limitations of natural probiotics and provides a promising approach for mitigating chemotherapy\u2010related cardiotoxicity via the gut\u2010heart axis.\n                  <\/jats:p>","DOI":"10.1002\/advs.202519344","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:18:13Z","timestamp":1778271493000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral Bioinspired Peroxisome\u2010Engineered Probiotics for Modulating Gut Microbiota Homeostasis and Alleviating Cardiac Chemotherapy Toxicity"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9730-7102","authenticated-orcid":false,"given":"Shuyu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology Cardiovascular Institute of Zhengzhou University The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"National Health Commission Key Laboratory of Cardiovascular Regenerative Medicine Central China Subcenter of National Center For Cardiovascular Diseases Henan Cardiovascular Disease Center Fuwai Central\u2010China Cardiovascular Hospital Central China Fuwai Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7690-1373","authenticated-orcid":false,"given":"Xiaowan","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Medicine of Henan University  Zhengzhou Henan China"},{"name":"Nanozyme Laboratory in Zhongyuan Henan Academy of Innovations in Medical Science  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Health Commission Key Laboratory of Cardiovascular Regenerative Medicine Central China Subcenter of National Center For Cardiovascular Diseases Henan Cardiovascular Disease Center Fuwai Central\u2010China Cardiovascular Hospital Central China Fuwai Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Han","sequence":"additional","affiliation":[{"name":"Nanozyme Laboratory in Zhongyuan Henan Academy of Innovations in Medical Science  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yike","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Metabolic Dysregulation &amp; Prevention and Treatment of Esophageal Cancer Tianjian Laboratory of Advanced Biomedical Sciences Academy of Medical Sciences Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Metabolic Dysregulation &amp; Prevention and Treatment of Esophageal Cancer Tianjian Laboratory of Advanced Biomedical Sciences Academy of Medical Sciences Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanozyme Laboratory in Zhongyuan Henan Academy of Innovations in Medical Science  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyue","family":"Xing","sequence":"additional","affiliation":[{"name":"National Health Commission Key Laboratory of Cardiovascular Regenerative Medicine Central China Subcenter of National Center For Cardiovascular Diseases Henan Cardiovascular Disease Center Fuwai Central\u2010China Cardiovascular Hospital Central China Fuwai Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"National Health 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