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However, its neurobiological function remains unclear. Herein, we reveal the specific expression of MINAR1 in somatostatin (SST)\u2010 and parvalbumin (PV)\u2010positive interneurons in the mouse forebrain. To explore its functional significance, MINAR1 conditional knockout (CKO) mice were generated from Nestin\u2010Cre mice. During postnatal growth, gross brain morphology and cytoarchitecture were comparable between MINAR1 CKO mice and littermate controls; adult CKO mice exhibited increased vulnerability to pentylenetetrazole (PTZ)\u2010induced seizures, and this phenotype was also present in SST\u2010Cre\u2013mediated CKO mice. Mechanistically, MINAR1 deficiency selectively impaired SST\n                    <jats:sup>+<\/jats:sup>\n                    (but not PV\n                    <jats:sup>+<\/jats:sup>\n                    ) interneuron excitability, reducing the inhibitory drive toward pyramidal neurons. This defect correlated with decreased G protein alpha S (G\u03b1s) levels and disrupted G\u03b1s\u2013cAMP signaling. Notably, pharmacological activation of adenylate cyclase with forskolin rescued this inhibitory defect. Collectively, our results establish MINAR1 as a key regulator of seizure susceptibility, likely via G\u03b1s\u2013cAMP\u2010dependent modulation of SST\n                    <jats:sup>+<\/jats:sup>\n                    interneurons, offering a molecular framework for developing targeted epilepsy therapies.\n                  <\/jats:p>","DOI":"10.1002\/advs.202519388","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:44:56Z","timestamp":1770277496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1\/G\u03b1s\u2013cAMP Signaling"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6444-3726","authenticated-orcid":false,"given":"Wei\u2010Tang","family":"Liu","sequence":"first","affiliation":[{"name":"Shanghai Institute of Infectious Disease and Biosecurity Fudan University  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