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Herein, we present triphenylphosphonium\u2010functionalized carbon dots supported by single\u2010atom silver (T\u2010Ag\n                    <jats:sub>SA<\/jats:sub>\n                    \u2010CDs) that integrate fluorescent antioxidant nanozymes for the accurate ROS scavenging and real\u2010time bioimaging of AKI. By anchoring silver in single\u2010atom and sub\u2010nanocluster states on a carbon dot matrix, T\u2010Ag\n                    <jats:sub>SA<\/jats:sub>\n                    \u2010CDs exhibit exceptional superoxide dismutase (SOD)\u2010 and glutathione peroxidase (GPx)\u2010like activities, surpassing traditional nanozymes in ROS neutralization efficiency. Density functional theory (DFT) calculations disclose a low\u2010energy reaction pathway common to both nitrogen\u2010doped carbon dots (N\u2010CDs) and Ag\n                    <jats:sub>SA<\/jats:sub>\n                    \u2010CDs, clarifying the mechanism behind their dual SOD\u2010 and GPx\u2010mimetic activities. The biocompatible N\u2010CDs platform guarantees the stability, minimizes Ag\n                    <jats:sup>+<\/jats:sup>\n                    \u2010associated toxicity, and enhances catalytic performance through synergistic Ag\n                    <jats:sub>SA<\/jats:sub>\n                    \u2010CD interactions. Targeting mitochondria through triphenylphosphonium functionalization facilitates site\u2010specific antioxidant protection, demonstrating robust therapeutic efficacy in a cisplatin\u2010induced AKI mouse model. Additionally, the intrinsic fluorescence of T\u2010Ag\n                    <jats:sub>SA<\/jats:sub>\n                    \u2010CDs facilitates non\u2010invasive monitoring of biodistribution and renal accumulation, promotes the recovery of damaged kidney tissue, alleviates oxidative stress and post\u2010cure assessment, and offers a self\u2010reported theranostic platform, while also aiming to improve its clinical application.\n                  <\/jats:p>","DOI":"10.1002\/advs.202519393","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T08:46:19Z","timestamp":1768466779000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Precision\u2010Engineered Silver Single\u2010Atom Carbon Dot Nanozymes for Theranostic Management of Acute Kidney Injury"],"prefix":"10.1002","volume":"13","author":[{"given":"Tianle","family":"Tang","sequence":"first","affiliation":[{"name":"NHC Key Laboratory 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