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Current biosensors largely focus on detecting soluble disease markers. Here, a peptide\u2010functionalized graphene biosensor is presented capable of platform\u2010independent, highly sensitive detection of specific immune receptors on living cells. Formyl peptide receptor 2 (FPR2) is targeted, a key modulator of innate immune cells, and validated the technology in two complementary formats: i) graphene\u2010enhanced surface plasmon resonance (SPR) as a robust optical benchmark, and ii) graphene field\u2010effect transistors (gFETs) as a compact, cost\u2010effective electrical alternative. Target specificity is first confirmed using HEK293T cells selectively overexpressing FPR2. Detection of FPR2 on primary human neutrophils is achieved with high reproducibility using fewer than 10\u00a0000 cells\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    , demonstrating both sensitivity and reliability. By demonstrating sensitive and reproducible detection across both optical and electrical platforms, this work bridges materials science and immunology, highlighting the potential of peptide\u2010functionalized graphene biosensors for point\u2010of\u2010care diagnostics, immune monitoring, and early sepsis triage.\n                  <\/jats:p>","DOI":"10.1002\/advs.202519436","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:34:13Z","timestamp":1765596853000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cross\u2010Platform Biosensing of Immune Receptors Using Peptide\u2010Functionalized Graphene"],"prefix":"10.1002","volume":"13","author":[{"given":"Ahmar","family":"Hasnain","sequence":"first","affiliation":[{"name":"Nanoelectronics &amp; Biosensing Lab Faculty of Computer Sciences and Microsystems Technology Kaiserslautern University of Applied Sciences  Amerikastr. 1 66482 Zweibr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Heilmann","sequence":"additional","affiliation":[{"name":"Molecular Immunology Lab Faculty of Computer Sciences and Microsystems Technology Kaiserslautern University of Applied Sciences  Amerikastr. 1 66482 Zweibr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabel","family":"Pohl","sequence":"additional","affiliation":[{"name":"Nanoelectronics &amp; Biosensing Lab Faculty of Computer Sciences and Microsystems Technology Kaiserslautern University of Applied Sciences  Amerikastr. 1 66482 Zweibr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Weber","sequence":"additional","affiliation":[{"name":"Molecular Immunology Lab Faculty of Computer Sciences and Microsystems Technology Kaiserslautern University of Applied Sciences  Amerikastr. 1 66482 Zweibr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Bufe","sequence":"additional","affiliation":[{"name":"Molecular Immunology Lab Faculty of Computer Sciences and Microsystems Technology Kaiserslautern University of Applied Sciences  Amerikastr. 1 66482 Zweibr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9109-619X","authenticated-orcid":false,"given":"Alexey","family":"Tarasov","sequence":"additional","affiliation":[{"name":"Nanoelectronics &amp; Biosensing Lab Faculty of Computer Sciences and Microsystems Technology Kaiserslautern University of Applied Sciences  Amerikastr. 1 66482 Zweibr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.4110\/in.2018.18.e27"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00046-08"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00687-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.626747"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05028-x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/admt.201800186"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/s24144670"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e13323"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12195-008-0028-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma17020333"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jz300033g"},{"key":"e_1_2_8_12_1","author":"Hasnain A.","year":"2025","journal-title":"Adv. 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