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Antigen\u2010presenting cells (APCs) orchestrate this process by presenting retinal antigens to na\u00efve CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells and driving their differentiation into autoreactive CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Here, we report an intestinal APCs\u2010targeted strategy for treating AU based on orally administered nanoCEL (diameter: 37.06\u00a0\u00b1\u00a00.12\u00a0nm), a pH\u2010responsive nanomedicine exhibiting a great gastric acid stability and a pH\u2010responsive drug release behavior. After oral administration, nanoCEL effectively penetrates the intestinal mucus barrier and targets APCs in the intestine. Using an experimental autoimmune uveitis rat model, oral administration of nanoCEL (2 mg\/kg) exhibits a superior therapeutic efficacy than free CEL treatment by suppressing the antigen\u2010presenting ability of APCs and impairing pathogenic T cell differentiation. Additionally, nanoCEL medication protects the BRB from the damage of pathogenic T cells by the reduction of the infiltration of peripheral immune cells and the activation of retinal glial cells. Compared to free CEL, oral administration of nanoCEL remarkably enhances drug bioavailability and improves biosafety without apparent systemic toxicity. Thus, the proposed APC\u2010targeted nanodrug delivery system might be a promising strategy to treat AU.\n                  <\/jats:p>","DOI":"10.1002\/advs.202519503","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T15:21:07Z","timestamp":1770132067000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral Celastrol Nanomedicine Targeting Intestinal Antigen\u2010Presenting Cells to Effectively Mitigate Autoimmune Uveitis via Gut\u2010Retina Axis"],"prefix":"10.1002","volume":"13","author":[{"given":"Jinrun","family":"Chen","sequence":"first","affiliation":[{"name":"National Engineering Research Center of Ophthalmology and Optometry Eye Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqin","family":"Wu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Ophthalmology and Optometry Eye Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bofei","family":"Xu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Ophthalmology and Optometry Eye Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiabei","family":"Hou","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Ophthalmology and Optometry Eye Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijing","family":"Li","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Ophthalmology and Optometry Eye Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhan","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials Ministry of Education, and College of Life Sciences Nankai University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutuo","family":"Zhu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Ophthalmology and Optometry Eye Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Ophthalmology and Optometry Eye Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuqi","family":"Feng","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Ophthalmology and Optometry Eye Hospital Wenzhou Medical University  Wenzhou 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