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In contrast, vaccination and natural viral infections can generate durable, high\u2010titer antiviral antibodies. A modular Programmed Death\u2010Ligand 1 (PD\u2010L1)\u2010binding antigen presenter (PBAP) has been engineered to tether varicella\u2010zoster virus (VZV) glycoprotein E (gE) to PD\u2010L1 expressed on tumor cell surfaces. This innovative construct leverages pre\u2010existing anti\u2010gE antibodies to trigger antibody\u2010dependent effector mechanisms. PBAP\u2010gE effectively bound to PD\u2010L1 positive tumor cells and, together with vaccine\u2010induced anti\u2010gE antibodies, potentiated NK cell\u2010mediated antibody\u2010dependent cellular cytotoxicity (ADCC) in vitro and induced significant tumor regression in murine models. The PBAP platform is modular and versatile. For example, a PBAP\u2010HER2 construct synergized with Herceptin and Kadcyla to eliminate human epidermal growth factor receptor 2 (HER2)\u2010negative, PD\u2010L1 positive cells. 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