{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:31:31Z","timestamp":1789515091496,"version":"build-2803163510"},"reference-count":138,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The principle \u201ctime is brain\u201d has long guided acute stroke treatment, emphasizing that earlier intervention improves outcomes. While this dictum applies to current gold\u2010standard reperfusion therapies, its relevance to emerging regenerative approaches such as stem cell therapy remains to be established. A growing body of preclinical and clinical studies suggests that timing of cell delivery is a key determinant of graft survival, integration and therapeutic efficacy, largely through interactions with the evolving post\u2010stroke microenvironment. Here, we discuss how early transplantation may access salvageable tissue but faces a hostile inflammatory microenvironment, whereas transplantation at the subacute or chronic phase benefits from a more permissive milieu but by then much of the tissue has been irreversibly lost. We further suggest the optimal window also depends on cell type and mechanism of action: neuroprotective or immunomodulatory grafts may benefit from earlier delivery, while cells requiring long\u2010term survival and integration may perform better later. Thus, \u201ctime is brain\u201d also applies to cell therapies, but it may require aligning graft delivery with the evolving post\u2010stroke microenvironment rather than the acute therapeutic window. Identifying biomarkers that track inflammatory changes, vascular remodeling and brain damage could personalize this \u201cwindow of receptivity\u201d and guide tailored future clinical trials.<\/jats:p>","DOI":"10.1002\/advs.202519579","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T09:36:58Z","timestamp":1763458618000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["\u201cTime Is Brain\u201d \u2013 for Cell Therapies"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0018-3228","authenticated-orcid":false,"given":"Hao","family":"Yin","sequence":"first","affiliation":[{"name":"Robarts Research Institute Schulich School of Medicine and Dentistry Western University  London Ontario N6A 5C1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6165-0355","authenticated-orcid":false,"given":"Dominikus","family":"Brian","sequence":"additional","affiliation":[{"name":"OrganoBit BioIntelligence Pte Ltd  Singapore 049422 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6912-3573","authenticated-orcid":false,"given":"Rebecca Z.","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neuroscience University of Southern California  Los Angeles CA 90033 USA"},{"name":"Zilkha Neurogenetic Institute Keck School of Medicine University of Southern California  Los Angeles CA 90033 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6170-4042","authenticated-orcid":false,"given":"Patrick D.","family":"Lyden","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neuroscience University of Southern California  Los Angeles CA 90033 USA"},{"name":"Zilkha Neurogenetic Institute Keck School of Medicine University of Southern California  Los Angeles CA 90033 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3376-3453","authenticated-orcid":false,"given":"Ruslan","family":"Rust","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neuroscience University of Southern California  Los Angeles CA 90033 USA"},{"name":"Zilkha Neurogenetic Institute Keck School of Medicine University of Southern California  Los Angeles CA 90033 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaf068"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000196957.55928.ab"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2020-016045"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00519-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706442"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804656"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713973"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00252-0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.044279"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.025436"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae204"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01064-1"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018290"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.02.004"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25585-5"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1905309116"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2019.05.006"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.207"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adg1323"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01711-x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20419"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00044"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201800640RR"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-025-03437-z"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.264442"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007642"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(02)00040-6"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20126"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600311"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.4.1005"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.12.1666"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200009000-00006"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/10738584221110100"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202504154"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-63725-3"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp174"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2936-16.2017"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4154"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-60187-5"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2017.12.017"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.358609"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123618"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02694-0"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaz6747"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-023-00301-7"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19892777"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19042-y"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2018.07.009"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2010.00638.x"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252212065"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2024.12.006"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127302"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963689719854342"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2017.06.005"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093735"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.09.084"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01739-y"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144218"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368911X589609"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22614"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0637"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2012-0147"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2000690117"},{"key":"e_1_2_9_64_1","first-page":"692","volume":"140","author":"Tornero D.","year":"2017","journal-title":"Brain"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2015.04.011"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.05.007"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-022-10501-1"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2014.05.017"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202417848"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.05.021"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52301-w"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202417664"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2023.08.014"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202415508"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-025-02214-w"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202302527"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2022.114177"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2023.0330"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-60540-8"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1411307"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.031657"},{"key":"e_1_2_9_82_1","volume":"70","author":"Lasek\u2010Bal A.","year":"2019","journal-title":"J. Physiol. Pharmacol. Off. J. Pol. Physiol. Soc."},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1177\/000331970505600610"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.05.022"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25115745"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb44100332"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X21992664"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16655551"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adx2369"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.841898"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09477-9"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay1913"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1159\/000488365"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.2221"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.1.113"},{"key":"e_1_2_9_96_1","first-page":"637","volume":"22","author":"Lansberg M. G.","year":"2001","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11112161"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24525"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.048785"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-015-1636-z"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012794"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2023.07.023"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.03.033"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19827944"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/234095"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368914X678562"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2012.10.015"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/128591"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.46582\/jsrm.0803011"},{"key":"e_1_2_9_110_1","volume-title":"Study of the Safety and Efficacy of Modified Stem Cells (SB623) in Patients with Chronic Motor Deficit From Ischemic Stroke","author":"SanBio, Inc","year":"2020"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30046-7"},{"key":"e_1_2_9_112_1","author":"Houkin K.","year":"2024","journal-title":"JAMA Neurol."},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1186\/scrt544"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.32"},{"key":"e_1_2_9_115_1","first-page":"bcr","volume":"12","author":"Zawadzki M.","year":"2019","journal-title":"BMJ Case Rep. CP"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2021-018190"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1253050"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00381"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-022-00736-4"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30513-X"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-322515"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-024-07988-z"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70269-1"},{"key":"e_1_2_9_124_1","doi-asserted-by":"crossref","unstructured":"J.Raman\u2010Nair G.Cron K.MacLeod B.Lacoste eNeuro2024 11 ENEURO.0400.","DOI":"10.1523\/ENEURO.0400-22.2023"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2016.01.007"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.5200"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2014.08.007"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2020-000834"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2014.7"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00405"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33134-x"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252413585"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-024-03722-3"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2024.1341373"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-024-03286-8"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.034947"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003379"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.601914"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202519579","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202519579","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202519579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T07:48:39Z","timestamp":1775980119000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202519579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,18]]},"references-count":138,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/advs.202519579"],"URL":"https:\/\/doi.org\/10.1002\/advs.202519579","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,18]]},"assertion":[{"value":"2025-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e19579"}}