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However, their biomedical applications are hindered by limited possibilities for specific integration within the delivery systems. In this study, inspired by antibody\u2010antigen binding, we present an unprecedented assembly strategy that leverages immunoaffinity\u2010mimetic interactions of peptide\u2010aptamer (Peptide\u2010Apt\n                    <jats:sub>CD63<\/jats:sub>\n                    ) conjugates targeting CD63 markers on MSC\u2010Exo, yielding a hierarchical microstructure to enhance SCI repair. The conjugate, serving as the microgel scaffold, is synthesized by grafting azide\u2010modified Apt\n                    <jats:sub>CD63<\/jats:sub>\n                    onto poly(propargyl cysteine\u2010\n                    <jats:italic>co<\/jats:italic>\n                    \u2010\u03b3\u2010propargyl\u2010\n                    <jats:sub>L<\/jats:sub>\n                    \u2010glutamate). It exhibits excellent antioxidant capability to mitigate oxidative stress and immune responses at the injury site. In addition, this conjugate constrains the tethered MSC\u2010Exo within the lesion site during administration, yet its nuclease susceptibility allows for the release of MSC\u2010Exo to promote the proliferation and migration of neural stem cells and to direct their differentiation into neurons rather than astrocytes. These synergistic effects ultimately enhance neuroregeneration, thereby promoting the motor function recovery of SCI mice. Our work represents a pioneering effort in harnessing the specificity of immunoaffinity\u2010mimetic interactions between aptamers and biomacromolecules for the high\u2010performance assembly of chemically vulnerable biologics, facilitating widespread applications across materials science and life science.\n                  <\/jats:p>","DOI":"10.1002\/advs.202519701","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T05:20:04Z","timestamp":1768022404000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Immunoaffinity\u2010Mimetic Assembly of Peptide\u2010Aptamer Conjugates and Stem Cell\u2010Derived Exosomes into Hierarchical Microgels for Spinal Cord Injury Repair"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1994-0540","authenticated-orcid":false,"given":"Dantong","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Polymeric Materials School of Materials Science and Engineering Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, School of Life Sciences and Technology Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Tongji Hospital Affiliated to Tongji University Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, School of Life Sciences and Technology Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Tongji Hospital Affiliated to Tongji University Tongji University  Shanghai 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