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Circular RNA is emerging as a critical regulator of gene expression. Here, we reported a novel circular RNA\n                    <jats:italic>circNrip1<\/jats:italic>\n                    formed by back\u2010splicing from exon 3 to exon 2 of the\n                    <jats:italic>Nrip1<\/jats:italic>\n                    pre\u2010RNA. Peripheral nerve injury upregulates\n                    <jats:italic>circNrip1<\/jats:italic>\n                    , but not\n                    <jats:italic>Nrip1<\/jats:italic>\n                    mRNA, in injured DRG neurons, at least in part due to increased binding of the RNA\u2010binding protein FUS to\n                    <jats:italic>Nrip1<\/jats:italic>\n                    pre\u2010RNA, thereby promoting\n                    <jats:italic>circNrip1<\/jats:italic>\n                    formation. Blocking this upregulation attenuates nerve injury\u2013induced increases in toll\u2010like receptor 2 (\n                    <jats:italic>Tlr2<\/jats:italic>\n                    ) mRNA and TLR2 protein levels in injured DRG, as well as nerve injury\u2013induced nociceptive hypersensitivity. Conversely, mimicking this upregulation elevates DRG\n                    <jats:italic>Tlr2<\/jats:italic>\n                    mRNA and TLR2 protein expression and produces neuropathic pain\u2010like symptoms in na\u00efve mice. Mechanistically, upregulated\n                    <jats:italic>circNrip1<\/jats:italic>\n                    enhances its binding to the 3\u2032\u2010 untranslated region (UTR) of\n                    <jats:italic>Tlr2<\/jats:italic>\n                    mRNA and to the RNA\u2010binding protein SYNCRIP, thereby recruiting more SYNCRIP to the\n                    <jats:italic>Tlr2<\/jats:italic>\n                    mRNA 3\u2032\u2010UTR and stabilizing\n                    <jats:italic>Tlr2<\/jats:italic>\n                    mRNA in injured DRG neurons. Thus,\n                    <jats:italic>circNrip1<\/jats:italic>\n                    contributes to neuropathic pain by promoting SYNCRIP\u2010triggered stabilization of TLR2 in DRG neurons and represents a promising therapeutic target for intervention.\n                  <\/jats:p>","DOI":"10.1002\/advs.202519740","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T03:36:14Z","timestamp":1775792174000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circular RNA\n                    <i>circNrip1<\/i>\n                    Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing\n                    <i>Tlr2<\/i>\n                    mRNA in Primary Sensory Neurons"],"prefix":"10.1002","volume":"13","author":[{"given":"Xiaozhou","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Anesthesiology New Jersey Medical School Rutgers The State University of 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