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Herein, we report the role of a series of chemically synthesized mannose\u2010capped arabinomannan motifs from\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    cell wall, including 18\u2010mer, 19\u2010mer, 27\u2010mer, and 101\u2010mer in regulating host immunity. As an influenza vaccine adjuvant, 101\u2010mer induced significantly enhanced anti\u2010influenza antibody response and immune protection compared with other arabinomannan motifs. 101\u2010mer elicited robust immunoenhancement while exhibiting a favorable tolerability profile, as it did not trigger any observable physiological toxicity or inflammatory reactions in various organs. Mechanistically, we found 101\u2010mer may serve as a Dectin\u20102 agonist to activate host immunity through Syk\/NF\u2010\u03baB signaling. This study provided a new oligosaccharide candidate that can satisfy the required \u201cefficacy\u2010safety\u201d balance for clinical adjuvant development.\n                  <\/jats:p>","DOI":"10.1002\/advs.202519843","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T14:59:22Z","timestamp":1770130762000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Identification of Mannose\u2010Capped\u2010Arabinomannan 101\u2010mer as a Potential Influenza Virus Vaccine Adjuvant"],"prefix":"10.1002","volume":"13","author":[{"given":"Yu\u2010Fang","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College  Kunming Yunnan P. R. 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