{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:37:15Z","timestamp":1790375835817,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"37","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32501134"],"award-info":[{"award-number":["32501134"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92478123"],"award-info":[{"award-number":["92478123"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370147"],"award-info":[{"award-number":["82370147"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32371336"],"award-info":[{"award-number":["32371336"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2025JC\u2010YBQN 260"],"award-info":[{"award-number":["2025JC\u2010YBQN 260"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Major histocompatibility complex class I (MHC\u2010I) proteins play a crucial role in immune surveillance by presenting newly synthesized antigens to CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells on the cell surface. The downregulation of MHC\u2010I impairs antigen presentation and facilitates immune evasion in bladder cancer. O\u2010GlcNAcylation, an O\u2010linked N\u2010acetylglucosamine modification that is upregulated in various cancers, is increasingly recognized for its role in immune regulation. However, its specific role in antigen presentation remains unclear. In this study, we identified an inverse correlation between O\u2010GlcNAcylation levels and immune cell infiltration, specifically reducing CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell numbers in bladder cancer. Reducing cellular O\u2010GlcNAcylation significantly enhanced antigen presentation efficiency. We demonstrated that O\u2010GlcNAcylation of antigen peptide transporter 1 (TAP1), a key transporter in the antigen presentation pathway, disrupts its interaction with MHC\u2010I, thereby promoting the autophagic\u2010lysosomal degradation of MHC\u2010I and impairing CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell\u2010mediated cytotoxicity. Inhibiting O\u2010GlcNAcylation of TAP1 significantly augmented antitumor immune responses. Collectively, these findings reveal a novel mechanism by which O\u2010GlcNAcylation facilitates immune evasion in bladder cancer and suggest a potential therapeutic strategy for enhancing TAP\/MHC\u2010I\u2010mediated antigen presentation.\n                  <\/jats:p>","DOI":"10.1002\/advs.202519955","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T09:03:22Z","timestamp":1777021402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["O\u2010GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer"],"prefix":"10.1002","volume":"13","author":[{"given":"Jinpeng","family":"Wu","sequence":"first","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China Provincial Key Laboratory of Biotechnology College of Life Sciences Ministry of Education Northwest University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueting","family":"Ren","sequence":"additional","affiliation":[{"name":"The Comprehensive Breast Care Center The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhai","sequence":"additional","affiliation":[{"name":"The Comprehensive Breast Care Center The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China Provincial Key Laboratory of Biotechnology College of Life Sciences Ministry of Education Northwest University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengqi","family":"Tan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China Provincial Key Laboratory of Biotechnology College of Life Sciences Ministry of Education Northwest University  Xi'an Shaanxi China"},{"name":"Shaanxi Province Key Laboratory of Molecular Cardiology School of Medicine Northwest University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazhen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China Provincial Key Laboratory of Biotechnology College of Life Sciences Ministry of Education Northwest University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Han","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China Provincial Key Laboratory of Biotechnology College of Life Sciences Ministry of Education Northwest University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Translational Medicine (IMTM) and Department of Biochemistry and Molecular Biology Xi'an Jiaotong University Health Science Center  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Guan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China Provincial Key Laboratory of Biotechnology College of Life Sciences Ministry of Education Northwest University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1857-0055","authenticated-orcid":false,"given":"Xiang","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China Provincial Key Laboratory of Biotechnology College of Life Sciences Ministry of Education Northwest University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418\u2010024\u201001434\u2010y"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI171164"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.455"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005496\u20101"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326\u20106066.CIR\u201018\u20100758"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.09.007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.02.013"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305922"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010023\u201001899\u20104"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388\u2010019\u20101045\u20106"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929\u2010020\u201000648\u20109"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1474042"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2020.100885"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2216796120"},{"key":"e_1_2_10_16_1","first-page":"25","article-title":"Genetic Manipulation of OGT Enhances NK Cell\u2010mediated Cytotoxicity in Tumor Immunity","volume":"1232","author":"Oh S.\u2010C.","year":"2025","journal-title":"Journal of Advanced Research"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456\u2010024\u201009947\u20103"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102229\u20105"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan6298"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007754\u2010w"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2107453119"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2019.11.003"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201020\u20100812"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.03.002"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2022.100228"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC08416E"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010024\u201001618\u20106"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164\u2010025\u201000693\u2010w"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326\u20106066.CIR\u201024\u20100127"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201034346\u2010x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12765"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010023\u201005937\u20103"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101465"},{"key":"e_1_2_10_34_1","article-title":"Targeting Peptide Antigens Using a Multiallelic MHC I\u2010Binding System","volume":"10","author":"Du H.","year":"2024","journal-title":"Nature Biotechnology"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI183656"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.818015"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010024\u201007327\u20109"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202519955","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202519955","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202519955","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:09:58Z","timestamp":1783112998000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202519955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,24]]},"references-count":36,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/advs.202519955"],"URL":"https:\/\/doi.org\/10.1002\/advs.202519955","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,24]]},"assertion":[{"value":"2025-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e19955"}}