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However, their effectiveness remains constrained by the lack of tactile feedback in confined spaces, reliance on manual dexterity, and dependence on radiation\u2010based imaging. Remotely controlled miniature soft robots that integrate tactile sensing, real\u2010time monitoring, and therapeutic delivery offer a promising route to overcome these barriers, but achieving such multifunctionality within a single device has yet to be realized. Here, we introduce an intelligent soft opto\u2010magnetic (iSOM) robot that integrates magnetic actuation, skin\u2010mimic tactile sensing, and photothermal ablation in a millimeter\u2010scale design. The robot comprises a compliant polymer sheath configured with optical pathways for sensing and therapeutic light delivery, a magnetically steerable body for controlled navigation, and a tissue\u2010conforming tip designed to provide tactile feedback and localized photothermal therapy. Driven by magnetic fields and laser excitation, the robot can actively navigate tortuous anatomy to perform targeted ablation therapy, while simultaneously providing real\u2010time feedback on both navigation and treatment to ensure precision and safety. Its capabilities were validated in proof\u2010of\u2010concept demonstrations, including real\u2010time tracked photothermal ablation in porcine tissue, targeted cardiac ablation in cardiovascular phantoms, and image\u2010guided therapeutic interventions in ex vivo and in vivo anatomical systems, underscoring its translational potential for high\u2010precision MII.<\/jats:p>","DOI":"10.1002\/advs.202520344","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T08:59:02Z","timestamp":1768985942000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Intelligent Soft Opto\u2010Magnetic Robot for Minimally Invasive Interventional Therapy"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3893-2319","authenticated-orcid":false,"given":"Jingjing","family":"Guo","sequence":"first","affiliation":[{"name":"School of Instrumentation and Optoelectronic 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