{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:43:38Z","timestamp":1793148218156,"version":"4.5.0"},"reference-count":69,"publisher":"Wiley","issue":"49","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371852"],"award-info":[{"award-number":["82371852"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472650"],"award-info":[{"award-number":["81472650"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    N6\u2010methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) modification and T\u2010cell metabolic reprogramming are increasingly recognized as critical drivers of inflammatory bowel disease (IBD). However, how the anti\u2010inflammatory cytokine interleukin\u201037 intersects with m\n                    <jats:sup>6<\/jats:sup>\n                    A\u2010mediated metabolic regulation remains unclear. Here, we show that IL\u201037 alleviates colitis by reducing global m\n                    <jats:sup>6<\/jats:sup>\n                    A levels and reshaping CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell metabolism. Mechanistically, IL\u201037 signals through its receptor SIGIRR to inhibit IRAK4 and JNK phosphorylation, suppress NF\u2010\u03baB p65 activation, and downregulate METTL14, thereby decreasing m\n                    <jats:sup>6<\/jats:sup>\n                    A deposition. The IL\u201037\/METTL14 axis notably reduces m\n                    <jats:sup>6<\/jats:sup>\n                    A enrichment at the A2445 site in the 3\u2032UTR of SLC2A1, destabilizing its mRNA and suppressing glycolysis. In vitro T\u2010cell polarization and adoptive transfer of METTL14\u2010overexpressing CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells confirmed that this metabolic shift restrains Th1\/Th17 differentiation while promoting Th2 expansion. Together, these findings reveal the IL\u201037\/SIGIRR\u2013METTL14\u2013m\n                    <jats:sup>6<\/jats:sup>\n                    A axis as a novel regulator of T\u2010cell metabolism and highlight SLC2A1 as a potential therapeutic target in IBD.\n                  <\/jats:p>","DOI":"10.1002\/advs.202520472","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T20:01:16Z","timestamp":1781035276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["m\n                    <sup>6<\/sup>\n                    A\u2010Mediated Glycolysis by IL\u201037 Drives T Cell Metabolic Reprogramming to Regulate Colitis"],"prefix":"10.1002","volume":"13","author":[{"given":"Xiaoyan","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiadong","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guolin","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanlian","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Yue","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulei","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linna","family":"Gu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxiang","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shishi","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenling","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nongyu","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinai","family":"Cui","sequence":"additional","affiliation":[{"name":"CDUTCM\u2010KEELE Joint Health and Medical Sciences Institute Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaijun","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Cardiology West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2320-9387","authenticated-orcid":false,"given":"Jiong","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01620-x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1290330"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01224-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01500-4"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-019-0168-5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23450"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abg0470"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-021-01316-8"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-024-00969-x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-022-00840-x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0379-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-025-00575-9"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110278"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.2RI0814-408R"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1278521"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.012"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-016-0782-4"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.012"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S474879"},{"key":"e_1_2_9_21_1","first-page":"22","article-title":"A Narrative Review of the IL\u201018 and IL\u201037 Implications in the Pathogenesis of Atopic Dermatitis and Psoriasis: Prospective Treatment Targets","volume":"25","author":"Rusiol L.","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.04.009"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.050"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3103"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22164-6"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-53307-0"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.178499"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2017.11.008"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-0435-8"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-05-078154"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abg0470"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01757-9"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-025-01310-w"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2312302"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-024-01008-6"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02141-x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-0644-z"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00450-x"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24678"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.08.006"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-023-01374-9"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab343"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abg0470"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.05.1061"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11162565"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13309"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3785"},{"key":"e_1_2_9_48_1","first-page":"1","article-title":"The Role of RNA Methylation in Tumor Immunity and its Potential in Immunotherapy","volume":"23","author":"Yan L.","year":"2024","journal-title":"Molecular Cancer"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01129-8"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21594-6"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-023-00643-4"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.04.001"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000001794"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09903-6"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10669-0"},{"key":"e_1_2_9_56_1","first-page":"e14548","article-title":"Targeting 6\u2010Phosphofructo\u20102\u2010Kinase (PFKFB3) as an Immunotherapeutic Strategy","volume":"12","author":"Jason C.","year":"2016","journal-title":"Journal of Clinical Oncology"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2024-3056"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202052348"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217194"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01220-7"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106253"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf476"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-025-03211-w"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202100209"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00820-z"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23450"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-017-0057-1"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12443"},{"key":"e_1_2_9_69_1","first-page":"43","article-title":"Site\u2010Specific m(6) A Erasing via Conditionally Stabilized CRISPR\u2010Cas13b Editor","volume":"62","author":"Xu Y.","year":"2023","journal-title":"Angewandte Chemie International Edition in English"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab517"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202520472","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202520472","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202520472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:24:24Z","timestamp":1788434664000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202520472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,9]]},"references-count":69,"journal-issue":{"issue":"49","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/advs.202520472"],"URL":"https:\/\/doi.org\/10.1002\/advs.202520472","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,9]]},"assertion":[{"value":"2025-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e20472"}}