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Terahertz (THz) waves have been explored as a promising approach to modulate the influx, which primarily target resonant interactions with chemical groups in channels. Here, we demonstrate a strategy that directly regulates the motion of confined Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ions within the selectivity filter via resonant THz waves. We characterize the ions' axial oscillations, identifying a distinct intrinsic frequency of 1.65 THz and two coherent modes. By tuning a THz electric field to this frequency, we induce a remarkable resonance excitation that lowers the energy barrier between binding sites, achieving a statistically significant enhancement of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    permeation in our model. Meanwhile, we show that the degree of coherence is precisely tunable by the resonant THz field and temperature. Furthermore, quantum mechanics analyses reveal transition frequencies and wavefunctions that validate the observed oscillation modes, confirming that the collective motion exhibits discrete quantum eigenstates. Our results introduce a proof\u2010of\u2010concept, ion\u2010targeted strategy for manipulating Ca\n                    <jats:sup>2+<\/jats:sup>\n                    permeation and propose a theoretical coherence mechanism for high\u2010flux ions transport. This work advances the understanding of ion channel physics via a mechanism\u2010oriented framework that lays the groundwork for exploring novel bio\u2010electromagnetic modulation.\n                  <\/jats:p>","DOI":"10.1002\/advs.202520475","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:28:38Z","timestamp":1771493318000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhancement of Calcium Ion Permeation via Resonant Coupling of Ion and Terahertz Waves in Voltage Gated Calcium Channels"],"prefix":"10.1002","volume":"13","author":[{"given":"Zihao","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Electronic Science and Engineering University of Electronic Science and Technology of China  Chengdu China"},{"name":"National Key Laboratory of Science and Technology on Vacuum Electronics University of Electronic Science and Technology of China  Chengdu 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Key Laboratory of Science and Technology on Vacuum Electronics University of Electronic Science and Technology of China  Chengdu China"},{"name":"Terahertz Radiation and Application Key Laboratory of Sichuan Province University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunchao","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Electronic Science and Engineering University of Electronic Science and Technology of China  Chengdu China"},{"name":"National Key Laboratory of Science and Technology on Vacuum Electronics University of Electronic Science and Technology of China  Chengdu China"},{"name":"Terahertz Radiation and Application Key Laboratory of Sichuan Province University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengpeng","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Electronic Science and Engineering University of Electronic Science and Technology of China  Chengdu China"},{"name":"National Key Laboratory of Science and Technology on Vacuum Electronics University of Electronic Science and Technology of China  Chengdu China"},{"name":"Terahertz Radiation and Application Key Laboratory of Sichuan Province University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaomeng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Electronic Science and Engineering University of Electronic Science and Technology of China  Chengdu China"},{"name":"National Key Laboratory of Science and Technology on Vacuum Electronics University of Electronic Science and Technology of China  Chengdu China"},{"name":"Terahertz Radiation and Application Key Laboratory of Sichuan Province University of Electronic Science and Technology of China  Chengdu 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