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We developed a ferritin\u2010based nanoplatform\u00a0(Fe\u2010SH@Fn) co\u2010delivering shikonin (SH) and Fe\n                    <jats:sup>3+<\/jats:sup>\n                    to synergistically induce ferroptosis and activate immunogenic cell death (ICD). Ferritin, a ligand for CD71, which is overexpressed on AML cells, enables tumor targeting and encapsulates Fe\u2010SH formed by coordination between SH and Fe\n                    <jats:sup>3+<\/jats:sup>\n                    .\u00a0In AML cells, high intracellular glutathione triggers Fe\u2010SH@Fn disassembly: Fe\n                    <jats:sup>3+<\/jats:sup>\n                    reduces to Fe\n                    <jats:sup>2+<\/jats:sup>\n                    to drive Fenton reaction\u2010mediated ferroptosis, while SH induces ICD. This dual effect boosts the release of damage\u2010associated molecular patterns, remodeling the microenvironment by promoting dendritic cell maturation, enhancing CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell infiltration, and reducing regulatory T cells. In vivo, Fe\u2010SH@Fn achieved 81.25% tumor growth inhibition in subcutaneous AML model and extended median survival by 2.8\u2010fold in orthotopic AML model without systemic toxicity. This work presents a translatable strategy that overcomes AML immunosuppression through targeted drug delivery and synergistic ferroptosis\u2010ICD activation.\n                  <\/jats:p>","DOI":"10.1002\/advs.202520544","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:02:41Z","timestamp":1772971361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["AML\u2010Targeted Metal\u2010Polyphenol Nanoplatform Induces Ferroptosis\u2010ICD Cascade\u00a0for Antitumor Immunity Boosting"],"prefix":"10.1002","volume":"13","author":[{"given":"Shangqin","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Hematology, School of Medicine, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu China"},{"name":"School of Pharmacy Southwest Medical University  Luzhou 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