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We present\n                    <jats:bold>GloPath<\/jats:bold>\n                    , an entity\u2010centric foundation model trained on over one million glomeruli extracted from 14 049 renal biopsy specimens using multi\u2010scale and multi\u2010view self\u2010supervised learning. GloPath addresses two major challenges in nephropathology: glomerular lesion assessment and clinicopathological insights discovery. For lesion assessment, GloPath was benchmarked across three independent cohorts on 52 tasks\u2014including lesion recognition, grading, few\u2010shot classification, and cross\u2010modality diagnosis\u2014outperforming state\u2010of\u2010the\u2010art methods in 42 tasks (80.8%). In the large\u2010scale real\u2010world study, it achieved an ROC\u2010AUC of 91.51% for lesion recognition, demonstrating strong robustness in routine clinical settings. For clinicopathological insights, GloPath systematically revealed statistically significant associations between glomerular morphological parameters and clinical indicators across 224 morphology\u2013clinical variable pairs, demonstrating its capacity to connect tissue\u2010level pathology with patient\u2010level outcomes. Together, these results position GloPath as a scalable and interpretable platform for glomerular lesion assessment and clinicopathological discovery, representing a step toward clinically translatable AI in renal\u00a0pathology.\n                  <\/jats:p>","DOI":"10.1002\/advs.202520580","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T15:40:48Z","timestamp":1776267648000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["GloPath: An Entity\u2010Centric Foundation Model for Glomerular Lesion Assessment and Clinicopathological Insights"],"prefix":"10.1002","volume":"13","author":[{"given":"Qiming","family":"He","sequence":"first","affiliation":[{"name":"Interdisciplinary Institute for Medical Engineering Fuzhou University  Fuzhou China"},{"name":"Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School Tsinghua University  Shenzhen China"},{"name":"Medical Optical Technology R&amp;D Center Research Institute of Tsinghua Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Basic Medicine and Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Guan","sequence":"additional","affiliation":[{"name":"Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School Tsinghua University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Engineering Science University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zimo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Engineering Science University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Basic Medicine and Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology Ankang Central Hospital Ankang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingming","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School Tsinghua University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Ge","sequence":"additional","affiliation":[{"name":"Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School Tsinghua University  Shenzhen China"},{"name":"Peng Cheng Laboratory Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yexing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jinan Inspur Data Technology Co., Ltd. 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