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In this study, based on allantoin\u2010loaded ZIF8 nanoparticles (Alla@ZIF8) and methacrylated quaternary ammonium carboxymethyl chitosan\/resveratrol composite hydrogels (RMQCC), we designed and developed an adaptive multifunctional hydrogel system (Alla@ZIF8\u2010Gel). This nanocomposite hydrogel exhibited multiple intelligent features, including pH\u2010responsiveness and morphological adaptability. The quaternary ammonium carboxymethyl chitosan imparted well biocompatibility and robust antimicrobial properties. Electrostatic interactions and hydrogen bonds endowed hydrogels with excellent injectability and self\u2010healing capabilities. The ZIF8 nanoparticles enabled the intelligent, on\u2010demand release of allantoin, thereby promoting tissue regeneration. Resveratrol conferred potent antioxidant, anti\u2010inflammatory, and immunomodulatory effects. The Alla@ZIF8\u2010Gel dynamically modulated drug release kinetics in response to the wound microenvironment, synergistically delivering antibacterial, antioxidant, anti\u2010inflammatory, and tissue\u2010regenerative functions. Both in vitro and in vivo experimental results demonstrated that this adaptive hydrogel markedly accelerated the healing of MRSA\u2010infected wounds, suppressed bacterial proliferation, alleviated oxidative damage and inflammatory responses, and enhanced collagen deposition, re\u2010epithelialization, and neovascularization. This work provides a novel design paradigm for the development of intelligent, multifunctional therapeutic materials for infected wound management, with significant translational potential for clinical application.<\/jats:p>","DOI":"10.1002\/advs.202520614","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:29:27Z","timestamp":1773664167000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Self\u2010Adaptive Allantoin@ZIF8 Nanocomposite Hydrogel with Resveratrol Synergy for MRSA\u2010Infected Wound Regeneration"],"prefix":"10.1002","volume":"13","author":[{"given":"Yongjie","family":"Zhu","sequence":"first","affiliation":[{"name":"Division of Spine Surgery Department of Orthopedic Surgery Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University  Nanjing 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