{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:58:20Z","timestamp":1781528300823,"version":"3.54.1"},"reference-count":57,"publisher":"Wiley","issue":"32","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100019537","name":"Science Fund for Distinguished Young Scholars of Hubei Province","doi-asserted-by":"publisher","award":["2024AFA097"],"award-info":[{"award-number":["2024AFA097"]}],"id":[{"id":"10.13039\/501100019537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401191"],"award-info":[{"award-number":["82401191"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370972"],"award-info":[{"award-number":["82370972"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201109"],"award-info":[{"award-number":["82201109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2024KJHZ0006"],"award-info":[{"award-number":["2024KJHZ0006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2022CFB636"],"award-info":[{"award-number":["2022CFB636"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Diverse material species, ranging from gold to ceramic, have been selected to construct dental implants in the past decades. However, existing implants are primarily designed to restore masticatory function yet fail to completely recover the sensory feedback of natural teeth.\u00a0Deprivation of sensory inputs impairs the perception of food texture and hinders the regulation of chewing force. This defect could result in unnecessary overload, leading to technical complications and biological failures, such as bone loss and temporomandibular joint damage, which remarkably limit their clinical outcomes. To endow the implanted tooth with masticatory perception, herein we demonstrate a 3D\u2010printed piezoelectric\u2010core\/robust\u2010sheath implanted tooth can rebuild the sensing feedback, serving as \u201cmechanoreceptors\u201d in converting mechanical chewing force to electrical signals, and up to brain through surrounding alveolar nerves. Working mechanism for the piezoelectric tooth has been revealed by real\u2010time tracing of neurological activities in the mouse brain in response to simulating occlusal stimulus. Furthermore, more than 90% patients in clinical cases subjectively admitted the rebuilding of their masticatory perception after being implanted the piezoelectric tooth. These findings substantially advance the field of smart implants and herald a promising avenue for medical engineering aimed at enhancing the multi\u2010functionality of implants in their applications.<\/jats:p>","DOI":"10.1002\/advs.202520786","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:20:11Z","timestamp":1774261211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Implanted Tooth That Can Feel"],"prefix":"10.1002","volume":"13","author":[{"given":"Yaru","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Neurobiology, School of Basic Medicine, Tongji Medical College Huazhong University of Science and Technology  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Materials Processing and Die &amp; Mould Technology, School of Materials Science and Engineering Huazhong University of Science and Technology  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan P. R. China"},{"name":"School of Stomatology, Tongji Medical College Huazhong University of Science and Technology  Wuhan P. R. China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Song","sequence":"additional","affiliation":[{"name":"School of Stomatology, Tongji Medical College Huazhong University of Science and Technology  Wuhan P. R. China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan P. R. China"},{"name":"Department of Stomatology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan P. R. China"},{"name":"School of Stomatology, Tongji Medical College Huazhong University of Science and Technology  Wuhan P. R. China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan P. R. China"},{"name":"School of Stomatology, Tongji Medical College Huazhong University of Science and Technology  Wuhan P. R. China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqi","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Child Healthcare, Department of Pediatrics, Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, School of Basic Medicine, Tongji Medical College Huazhong University of Science and Technology  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan P. R. China"},{"name":"School of Stomatology, Tongji Medical College Huazhong University of Science and Technology  Wuhan P. R. China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan P. R. China"},{"name":"School of Stomatology, Tongji Medical College Huazhong University of Science and Technology  Wuhan P. R. China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Stomatology Affiliated Hospital of Chifeng University  Mongolia P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, School of Basic Medicine, Tongji Medical College Huazhong University of Science and Technology  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7122-6694","authenticated-orcid":false,"given":"Bin","family":"Su","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Materials Processing and Die &amp; Mould Technology, School of Materials Science and Engineering Huazhong University of Science and Technology  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5315-7122","authenticated-orcid":false,"given":"Yumei","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan P. R. China"},{"name":"School of Stomatology, Tongji Medical College Huazhong University of Science and Technology  Wuhan P. R. China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj13070303"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14926"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010024\u201004146\u20104"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2007.01453.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13254"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jopr.12260"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511417442"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.120713"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jopr.70005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2025.06.024"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345241256306"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201099923\u20108"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368\u2010025\u201000354\u2010y"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345251329376"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2006080304"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201007819\u2010z"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2020.11.011"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202303942"},{"key":"e_1_2_8_20_1","first-page":"26","article-title":"A Systematic Review of 3D Printing in Autologous Breast Reconstruction","volume":"11","author":"Carrion K.","year":"2024","journal-title":"Plastic and Aesthetic Research"},{"issue":"3","key":"e_1_2_8_21_1","first-page":"25","article-title":"3D printing Technology: Driving Pioneering Innovations in Anti\u2010cancer Drug Delivery Systems","volume":"11","author":"Ma J.","year":"2025","journal-title":"International Journal of Bioprinting"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.20517\/2347-9264.2024.15"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmt.2024.09.001"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13185353"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jerd.12675"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jopr.13522"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748\u20106041\/10\/2\/025012"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.01.023"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2025.2540647"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5CP01118C"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma18081888"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34477"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c23946"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NR00111B"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202101333"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003\u20109969(00)00089\u20103"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2005.10.010"},{"issue":"3","key":"e_1_2_8_38_1","first-page":"39","article-title":"Bite Force of Children and Adolescents: A Systematic Review and Meta\u2010analysis","volume":"47","author":"Jayakumar P.","year":"2023","journal-title":"Journal of Clinical Pediatric Dentistry"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/12.2.148"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13102\u2010025\u201001208\u20100"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.157552"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134854"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000003206"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010021\u201003497\u20106"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26136526"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003\u20109969(98)00073\u20109"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2020.10.022"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050355"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520941837"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102842.2006.01629.x"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2017.07.011"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100501.1991.020205.x"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345251317429"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58040501"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/43860468"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266\u2010012\u20100072\u20103"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102842.2010.02197.x"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102842.2011.02235.x"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202520786","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202520786","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202520786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:43:36Z","timestamp":1781527416000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202520786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":57,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/advs.202520786"],"URL":"https:\/\/doi.org\/10.1002\/advs.202520786","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]},"assertion":[{"value":"2025-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e20786"}}