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Here, a metabolic\u2010epigenetic axis is identified in which Mapk13 phosphorylates Tcf1 at T289, enabling Tcf1 to activate the amino acid transporter Slc7a5 and enhance methionine uptake. This rewires one\u2010carbon metabolism and increases H3K4me3 enrichment at the\n                    <jats:italic>Tcf7<\/jats:italic>\n                    locus, thereby maintaining stem\u2010like CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells within rejecting grafts. Disruption of this circuit\u2010via genetic deletion of Mapk13 or Slc7a5, or through dietary methionine restriction\u2010reduces Tcf1\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell stemness and prevents CAV in mouse models. These findings reveal the Mapk13\u2010Tcf1\u2010Slc7a5 axis as a critical metabolic dependency of pathogenic T cells and highlight one\u2010carbon metabolism as a promising target to promote long\u2010term graft survival.\n                  <\/jats:p>","DOI":"10.1002\/advs.202520815","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T19:07:44Z","timestamp":1768504064000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting the Mapk13\u2010Tcf1\u2010Slc7a5 Axis via One\u2010Carbon Metabolic Regulation to Prevent Chronic Allograft Vasculopathy"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2333-8321","authenticated-orcid":false,"given":"Wang","family":"Yi","sequence":"first","affiliation":[{"name":"Institute of Organ Transplantation Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei 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