{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T07:31:16Z","timestamp":1789889476203,"version":"4.0.1"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Castration\u2010resistant prostate cancer (CRPC) chemotherapy resistance remained a significant clinical challenge. Prostate tumor stem cells (PCSCs) played a crucial role in chemotherapy resistance, but the underlying mechanisms were not fully understood. This study investigated how ADAMTS9\u2010AS2 reduced chemotherapy resistance in CRPC through a dual mechanism and explored the potential of polymeric materials targeting PCSCs and enhancing chemotherapy sensitivity. Key regulatory molecules of PCSCs were identified through mRNAsi\u2010based multi\u2010center patient cohorts. The effect of ADAMTS9\u2010AS2 on reducing docetaxel resistance in CRPC was assessed, and its mechanisms were further explored using in vitro and in vivo experiments. Finally, polymeric materials containing TGF\u2010\u03b2 inhibitor, ferroptosis inducer, and miR\u2010182\u20105p inhibitor were used to target PCSCs to improve chemotherapy sensitivity. ADAMTS9\u2010AS2 reduced CRPC chemotherapy resistance through dual mechanisms: (1) regulating FOXF2\/TGF\u2010\u03b22 axis to suppress PCSCs stemness; (2) encoding a short peptide that competitively retained more SLC7A11 in the cytoplasm than on the cytomembrane, thus promoting ferroptosis. Furthermore, polymeric materials targeting PCSCs significantly enhanced docetaxel sensitivity and inhibited tumor progression. ADAMTS9\u2010AS2 delayed docetaxel resistance by suppressing CRPC stemness and inducing ferroptosis. The use of polymeric materials targeting PCSCs offered a novel strategy to overcome CRPC chemotherapy resistance.<\/jats:p>","DOI":"10.1002\/advs.202520838","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T09:21:36Z","timestamp":1767000096000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["ADAMTS9\u2010AS2 Disrupts Docetaxel\u2010Resistance in Castration\u2010Resistant Prostate Cancer via Stemness Suppression and Ferroptosis Induction"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8869-9463","authenticated-orcid":false,"given":"Ji","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Urology, School of Medicine, Shanghai Tenth People's Hospital Tongji University  Shanghai P. R. China"},{"name":"School of Medicine, Shanghai Tenth People's Hospital Tongji University  Shanghai P. R. 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