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Here, iron oxide nanocubes (FeNCs) are developed that are conjugated with an antibody against the extracellular portion of TRPV1, and they are named FeNCs\u2010TRPV1. In F11 cell line and primary dorsal root ganglion neurons, FeNCs\u2010TRPV1 specifically activate TRPV1 channels and trigger Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx through magnetothermal effect under an alternating current magnetic field (ACMF). Intraspinally injected FeNCs\u2010TRPV1 induced TRPV1 desensitization in rats exposed to repetitive and transient ACMF before ischemia, resulting in the inhibition of TRPV1\u2010mediated Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling and neuropeptide release in the spinal cord during myocardial ischemia and reperfusion. Consequently, FeNCs\u2010TRPV1 reduce cardiac injury and ventricular arrhythmia, enhance the activity of prosurvival kinases, and inhibit myocardial cell apoptosis. These findings suggest that magnetic nanomaterials\u2010mediated remote regulation of spinal TRPV1 can be a novel non\u2010invasive neuromodulation therapy for the treatment of myocardial ischemia\u2010reperfusion (IR) injury.\n                  <\/jats:p>","DOI":"10.1002\/advs.202520852","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T01:47:36Z","timestamp":1765590456000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Remote Activation of Spinal TRPV1 by Magnetic Nanocubes Confers Cardioprotection Against Myocardial Ischemia\u2010Reperfusion Injury"],"prefix":"10.1002","volume":"13","author":[{"given":"Xueying","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine The Second Affiliated Hospital of Anhui Medical University Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education 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