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Here, we present a conformable wearable ultrasound system that combines lens\u2010assisted acoustic focusing with machine\u2010learning regression to enable non\u2010invasive bladder volume estimation, while providing a clear path toward future real\u2010time implementation. A flexible PZT array integrated with a concave acoustic lens enhances lateral energy concentration and depth selectivity, while a Random Forest model was used to map echo\u2010derived features to bladder volume estimates. In a pilot study, bladder\u2010volume estimates generated offline after data collection showed good agreement with a benchtop electrical impedance\u2010based measurement system, supporting the feasibility of non\u2010invasive bladder volume estimation. The device was operated using conservative low\u2010voltage, low\u2010duty\u2010cycle excitation settings designed to minimize acoustic exposure and be consistent with diagnostic\u2010ultrasound safety guidance, and biocompatible, flexible encapsulation is designed to support extended wear. Together with compact packaging and low\u2010power wireless transmission, these attributes support ambulatory, longitudinal bladder monitoring and offer design insights for future wearable ultrasound systems targeting precise and ultimately continuous physiological monitoring.<\/jats:p>","DOI":"10.1002\/advs.202520926","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:27:33Z","timestamp":1768908453000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Integrated Ultrasound Device for Precision Bladder Volume Monitoring via Acoustic Focusing and Machine Learning"],"prefix":"10.1002","volume":"13","author":[{"given":"Long Long","family":"Cao","sequence":"first","affiliation":[{"name":"The Affiliated Taian City Central Hospital of Qingdao University Qingdao University  Taian China"},{"name":"School of Automation Qingdao University  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng Wen","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Automation Qingdao University  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Xue","sequence":"additional","affiliation":[{"name":"The Affiliated Taian City Central Hospital of Qingdao University Qingdao University  Taian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulei","family":"Liu","sequence":"additional","affiliation":[{"name":"The Affiliated Taian City Central Hospital of Qingdao University Qingdao University  Taian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8446-1861","authenticated-orcid":false,"given":"Ming Liang","family":"Jin","sequence":"additional","affiliation":[{"name":"The Affiliated Taian City Central Hospital of Qingdao University Qingdao University  Taian China"},{"name":"School of Automation Qingdao University  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2023.04.008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fjurol.2024.102846"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/s21144893"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-021-02395-x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1677-5538.ibju.2020.1100"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/luts.12325"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jjns.12557"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fjurol.2025.102870"},{"issue":"3","key":"e_1_2_8_10_1","article-title":"Wearable Technology Applications in Healthcare: A Literature Review","volume":"23","author":"Wu M.","year":"2019","journal-title":"On\u2010Line Journal of Nursing Informatics"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41528-021-00107-x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-01800-0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05498-z"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41928-024-01271-4"},{"issue":"01","key":"e_1_2_8_15_1","first-page":"142","article-title":"A Review of Wearable Technology in Healthcare: Monitoring Patient Health and Enhancing Outcomes","volume":"7","author":"Adeghe E. 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