{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:39:01Z","timestamp":1789429141331,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"51","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770407"],"award-info":[{"award-number":["81770407"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2024206491"],"award-info":[{"award-number":["H2024206491"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Mitochondrial damage in dorsal root ganglion (DRG) neurons contributes to the pathogenesis of paclitaxel (PTX)\u2010induced peripheral neuropathic pain (PIPNP). Fibroblast growth factor 13 (FGF13), abundantly expressed in DRG neurons, is crucial for the regulation of somatosensation; however, its role in PIPNP remains unclear. Here, we demonstrated that FGF13 expression is upregulated in DRG neurons of PIPNP model mice. Conditional knockout of\n                    <jats:italic>Fgf13<\/jats:italic>\n                    in DRG neurons effectively alleviates PTX\u2010induced mitochondrial damage and neuropathic pain. RNA sequencing analysis revealed that mitophagy mediates the regulatory effects of FGF13 in PIPNP. Mechanistically, FGF13 physically interacts with vasohibin 1 (VASH1), regulating the binding of VASH1 to microtubules and promoting microtubule detyrosination. FGF13 ablation disrupts assembly of the FGF13\u2010VASH1\u2010\u03b1\u2010tubulin ternary complex, impairing VASH1\u2010mediated microtubule detyrosination and increasing microtubule tyrosination. The resulting accumulation of tyrosinated microtubules facilitates kinesin\u20103 (KIF1A)\u2010driven lysosomal trafficking, which in turn promotes mitophagy activation and ultimately ameliorates PTX\u2010induced mitochondrial damage and PIPNP. Furthermore, VASH1 overexpression in DRG neurons reversed the alleviating effects of FGF13 deficiency on PTX\u2010induced mitochondrial damage and PIPNP. In summary, our findings demonstrate that FGF13 deficiency alleviates mitochondrial dysfunction and PIPNP by suppressing VASH1\u2010dependent microtubule detyrosination and subsequently activating mitophagy. Targeting FGF13 may be a promising therapeutic strategy for PIPNP.\n                  <\/jats:p>","DOI":"10.1002\/advs.202520995","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T09:04:32Z","timestamp":1781773472000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["FGF13 Deficiency Ameliorates Paclitaxel\u2010Induced Neuropathic Pain by Inhibiting VASH1\u2010Mediated Microtubule Detyrosination to Promote Mitophagy"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8546-4669","authenticated-orcid":false,"given":"Yiming","family":"Dong","sequence":"first","affiliation":[{"name":"Key Laboratory of New Drug Pharmacology and Toxicology Key Laboratory of Neural and Vascular Biology Ministry of Education Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of New Drug Pharmacology and Toxicology Key Laboratory of Neural and Vascular Biology Ministry of Education Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simeng","family":"Lv","sequence":"additional","affiliation":[{"name":"Key Laboratory of New Drug Pharmacology and Toxicology Key Laboratory of Neural and Vascular Biology Ministry of Education Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zishan","family":"Dong","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Critical Disease Mechanism and Intervention Department of Pathophysiology Neuroscience Research Center Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixi","family":"Zhi","sequence":"additional","affiliation":[{"name":"Key Laboratory of New Drug Pharmacology and Toxicology Key Laboratory of Neural and Vascular Biology Ministry of Education Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhua","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of New Drug Pharmacology and Toxicology Key Laboratory of Neural and Vascular Biology Ministry of Education Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Basic Medicine Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoxi","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Basic Medicine Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Hebei University Clinical Medical College Hebei University Baoding China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Cheng","sequence":"additional","affiliation":[{"name":"College of Basic Medical Sciences Hebei University  Baoding China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3144-7094","authenticated-orcid":false,"given":"Chuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of New Drug Pharmacology and Toxicology Key Laboratory of Neural and Vascular Biology Ministry of Education Hebei Medical University  Shijiazhuang China"},{"name":"Affiliated Hospital of Hebei University Clinical Medical College Hebei University Baoding China"},{"name":"Department of Pharmacology Hebei Medical University  Shijiazhuang China"},{"name":"College of Pharmaceutical Sciences Key Laboratory of Medicinal Chemistry and Molecular Diagnosis College of Life Sciences Ministry of Education Hebei University  Baoding China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2022.100881"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2021.1954241"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2008.01.008"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2023.1264668"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01399"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2014.12.004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175288"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640\u2010022\u201000582\u20108"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S185873"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew309"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01503-7"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.79876"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370219868960"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115626"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.10.062"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.11.018"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.11.065"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000893"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.247957"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202503579"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2020.12.009"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010025\u201002607\u20105"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202400096R"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.04.046"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao4165"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao5676"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abn6020"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315947"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116329"},{"issue":"12","key":"e_1_2_9_31_1","first-page":"1802","article-title":"Inducible Fgf13 Ablation Alleviates Cardiac Fibrosis via Regulation of Microtubule Stability","volume":"56","author":"Wang C.","year":"2024","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15137"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhac012"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.373"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020104705"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658\u2010019\u20100164\u2010y"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.09.004"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26073195"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010023\u201000930\u20108"},{"issue":"12","key":"e_1_2_9_40_1","first-page":"1802","article-title":"Inducible Fgf13 Ablation Alleviates Cardiac Fibrosis via Regulation of Microtubule Stability","volume":"56","author":"Wang C.","year":"2024","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2021.12.006"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2018.07.006"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.06.008"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594\u2010019\u20100241\u2010y"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.01.009"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/gene.20010"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2017.01.009"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.02.020"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00453"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202520995","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202520995","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202520995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T08:24:06Z","timestamp":1789374246000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202520995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,18]]},"references-count":48,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/advs.202520995"],"URL":"https:\/\/doi.org\/10.1002\/advs.202520995","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,18]]},"assertion":[{"value":"2025-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e20995"}}