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Here, a cryo\u2010responsive liquid metal (LM) nanotransformer platform is developed. It undergoes dramatic deformation under freezing, physically disrupting lysosomal membranes and inducing potent cytotoxicity, particularly against drug\u2010resistant tumors, thus offering a broadly applicable pan\u2010cancer treatment. To enhance deformation efficiency of LM transformers, bismuth (Bi) is incorporated into gallium (Ga) to form biphasic Bi\u2010Ga alloy particles, which reduces Ga supercooling and promotes crystallization during freezing. The biosafety of LM particles is evaluated across multiple organoid models upon maximum contact. Based on 11 tumor organoid models including lung, colorectal, and ovarian cancers, the significant anti\u2010tumor effects of LM\u2010assisted cryotherapy are demonstrated, particularly Bi\u2010Ga combined with chemotherapy illustrating the strongest anti\u2010tumor efficacy. Transcriptomic analysis reveals LM anti\u2010tumor mechanism on multiple cancers with altering gene expression related to necroptosis, metabolic regulation, and cellular stress. In addition, tumors receiving LM cryo\u2010treatment exhibited hallmark features of immunogenic cell death. In immune\u2010competent drug\u2010resistant lung organoids, Bi\u2010Ga cryo\u2010treatment modulates tumor microenvironment and enhances immunogenicity. Collectively, this study establishes a universal LM nanotransformer\u2010enabled pan\u2010cancer strategy, offering a clinically viable and drug\u2010free approach for overcoming drug resistance.<\/jats:p>","DOI":"10.1002\/advs.202521041","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:52:39Z","timestamp":1776081159000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Liquid Metal Nanotransformers for Drug\u2010Resistant Pan\u2010Cancer Therapy in Patient\u2010Derived Organoids"],"prefix":"10.1002","volume":"13","author":[{"given":"Xiaojie","family":"Yuan","sequence":"first","affiliation":[{"name":"Changping National Laboratory  Beijing China"},{"name":"Department of Chemical Engineering Tsinghua University  Beijing 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